(1R,2R)-1-t-butyldimethylsiloxymethyl-1,2-dimethyl-2-(2-triphenylmethoxyethyl)cyclopentane

Base Information

Chemical Name:(1R,2R)-1-t-butyldimethylsiloxymethyl-1,2-dimethyl-2-(2-triphenylmethoxyethyl)cyclopentane
CAS No.:130735-37-4
Molecular Formula:C₃₅H₄₈O₂Si
Molecular Weight:528.85
Hs Code.:

Synonyms:(1R,2R)-1-t-butyldimethylsiloxymethyl-1,2-dimethyl-2-(2-triphenylmethoxyethyl)cyclopentane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R)-1-t-butyldimethylsiloxymethyl-1,2-dimethyl-2-(2-triphenylmethoxyethyl)cyclopentane

Chemical Property:

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Technology Process of (1R,2R)-1-t-butyldimethylsiloxymethyl-1,2-dimethyl-2-(2-triphenylmethoxyethyl)cyclopentane

There total 8 articles about (1R,2R)-1-t-butyldimethylsiloxymethyl-1,2-dimethyl-2-(2-triphenylmethoxyethyl)cyclopentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 130852-52-7
(1R,2R)-1,2-dimethyl-2-(2-triphenylmethoxyethyl)cyclopentanemethanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 130735-37-4
(1R,2R)-1-t-butyldimethylsiloxymethyl-1,2-dimethyl-2-(2-triphenylmethoxyethyl)cyclopentane

Guidance literature:: With 1H-imidazole; dmap; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1016/S0040-4020(01)86756-9

Reference yield:

: 125318-22-1
(1R*,6R*)-1,6-dimethyl-3-oxabicyclo<4.3.0>nonan-4-one

: 130735-37-4
(1R,2R)-1-t-butyldimethylsiloxymethyl-1,2-dimethyl-2-(2-triphenylmethoxyethyl)cyclopentane

Guidance literature:: Multi-step reaction with 8 steps

1: 91 percent / LiAlH₄ / diethyl ether / Ambient temperature

2: 64 percent / NEt₃, DMAP / dimethylformamide / Ambient temperature

3: 98 percent / oxalyl chloride, DMSO, NEt₃ / CH₂Cl₂ / 1) -70 deg C, 15 min, 2) -70 deg C to RT

4: 1) oxalyl chloride, DMSO, NEt₃, 2) p-TsOH / 1) CH₂Cl₂, a) -70 deg C, 15 min, b) -70 deg C to RT, 2) benzene, 2h, reflux

5: 98 percent / 2N HCl / acetone / Ambient temperature

6: 86 percent / LiAlH₄ / diethyl ether / Ambient temperature

7: 64 percent / NEt₃, DMAP / dimethylformamide / Ambient temperature

8: 99 percent / imidazole, DMAP / dimethylformamide / Ambient temperature

With 1H-imidazole; hydrogenchloride; dmap; lithium aluminium tetrahydride; oxalyl dichloride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4020(01)86756-9

Reference yield:

: 130735-35-2
(1R*,2R*)-1,2-dimethyl-2-(2-triphenylmethoxyethyl)cyclopentanecarbaldehyde

: 130735-37-4
(1R,2R)-1-t-butyldimethylsiloxymethyl-1,2-dimethyl-2-(2-triphenylmethoxyethyl)cyclopentane

Guidance literature:: Multi-step reaction with 5 steps

1: 1) oxalyl chloride, DMSO, NEt₃, 2) p-TsOH / 1) CH₂Cl₂, a) -70 deg C, 15 min, b) -70 deg C to RT, 2) benzene, 2h, reflux

2: 98 percent / 2N HCl / acetone / Ambient temperature

3: 86 percent / LiAlH₄ / diethyl ether / Ambient temperature

4: 64 percent / NEt₃, DMAP / dimethylformamide / Ambient temperature

5: 99 percent / imidazole, DMAP / dimethylformamide / Ambient temperature

With 1H-imidazole; hydrogenchloride; dmap; lithium aluminium tetrahydride; oxalyl dichloride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; In diethyl ether; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4020(01)86756-9