E/Z-3-(3-chloro-2-fluorobenzylidene)-6-fluoro-1,3-dihydropyrrolo[3,2-b]pyridin-2-one

Base Information

• Chemical Name: E/Z-3-(3-chloro-2-fluorobenzylidene)-6-fluoro-1,3-dihydropyrrolo[3,2-b]pyridin-2-one
• CAS No.: 1360822-15-6
• Molecular Formula: C₁₄H₇ClF₂N₂O
• Molecular Weight: 292.672
• Mol file: 1360822-15-6.mol

Synonyms:E/Z-3-(3-chloro-2-fluorobenzylidene)-6-fluoro-1,3-dihydropyrrolo[3,2-b]pyridin-2-one

Chemical Property of E/Z-3-(3-chloro-2-fluorobenzylidene)-6-fluoro-1,3-dihydropyrrolo[3,2-b]pyridin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of E/Z-3-(3-chloro-2-fluorobenzylidene)-6-fluoro-1,3-dihydropyrrolo[3,2-b]pyridin-2-one

There total 1 articles about E/Z-3-(3-chloro-2-fluorobenzylidene)-6-fluoro-1,3-dihydropyrrolo[3,2-b]pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-fluoro-3-chlorobenzaldehyde (85070-48-0) + 6-fluoro-1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one (136888-22-7) → E/Z-3-(3-chloro-2-fluorobenzylidene)-6-fluoro-1,3-dihydropyrrolo[3,2-b]pyridin-2-one (1360822-15-6)

Guidance literature:

With piperidine; In methanol; at 20 ℃;

Reference yield: 33.0%

4-{2-[3,3-dimethyl-but-(E)-ylideneamino]acetylamino}-3-methoxybenzoic acid methyl ester (1345866-83-2) + E/Z-3-(3-chloro-2-fluorobenzylidene)-6-fluoro-1,3-dihydropyrrolo[3,2-b]pyridin-2-one (1360822-15-6) → methyl rac-4-((2S,3S,4S,5R)-4-(3-chloro-2-fluorophenyl)-6'-fluoro-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-b]pyridine]-5-ylcarboxamido)-3-methoxybenzoate

Guidance literature:

E/Z-3-(3-chloro-2-fluorobenzylidene)-6-fluoro-1,3-dihydropyrrolo[3,2-b]pyridin-2-one; With lithium hydroxide; In tetrahydrofuran; at 40 ℃; for 0.166667h;

4-{2-[3,3-dimethyl-but-(E)-ylideneamino]acetylamino}-3-methoxybenzoic acid methyl ester; In tetrahydrofuran; at 40 ℃; for 24h;

Reference yield: 17.0%

acetic acid 2-(4-{2-[3,3-dimethyl-but-(E)-ylideneamino]-acetylamino}-3-methoxy-phenoxy)-ethyl ester (1360822-12-3) + E/Z-3-(3-chloro-2-fluorobenzylidene)-6-fluoro-1,3-dihydropyrrolo[3,2-b]pyridin-2-one (1360822-15-6) → rac-(2S,3S,4S,5R)-4-(3-chloro-2-fluorophenyl)-N-[4-(2-hydroxyethoxy)-2-methoxyphenyl]-6'-fluoro-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-b]pyridine]-5-carboxamide

Guidance literature:

E/Z-3-(3-chloro-2-fluorobenzylidene)-6-fluoro-1,3-dihydropyrrolo[3,2-b]pyridin-2-one; With lithium hydroxide; In tetrahydrofuran; at 40 ℃; for 0.166667h;

acetic acid 2-(4-{2-[3,3-dimethyl-but-(E)-ylideneamino]-acetylamino}-3-methoxy-phenoxy)-ethyl ester; In tetrahydrofuran; at 40 ℃; for 3h;

With water; sodium hydroxide; In tetrahydrofuran; at 40 ℃; for 1h;

upstream raw materials:

2-fluoro-3-chlorobenzaldehyde

6-fluoro-1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one