(2S)-1-(t-butyldiphenylsiloxy)-2-(p-methoxybenzyloxy)-24,28-di(tetrahydro-2H-pyran-2-yloxy)octacosane

Base Information

Chemical Name:(2S)-1-(t-butyldiphenylsiloxy)-2-(p-methoxybenzyloxy)-24,28-di(tetrahydro-2H-pyran-2-yloxy)octacosane
CAS No.:915024-77-0
Molecular Formula:C₆₂H₁₀₀O₇Si
Molecular Weight:985.557
Hs Code.:

Synonyms:(2S)-1-(t-butyldiphenylsiloxy)-2-(p-methoxybenzyloxy)-24,28-di(tetrahydro-2H-pyran-2-yloxy)octacosane

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Chemical Property of (2S)-1-(t-butyldiphenylsiloxy)-2-(p-methoxybenzyloxy)-24,28-di(tetrahydro-2H-pyran-2-yloxy)octacosane

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Technology Process of (2S)-1-(t-butyldiphenylsiloxy)-2-(p-methoxybenzyloxy)-24,28-di(tetrahydro-2H-pyran-2-yloxy)octacosane

There total 12 articles about (2S)-1-(t-butyldiphenylsiloxy)-2-(p-methoxybenzyloxy)-24,28-di(tetrahydro-2H-pyran-2-yloxy)octacosane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 914936-51-9
(2S)-1-(t-butyldiphenylsiloxy)-2-(p-methoxybenzyloxy)-28-(tetrahydro-2H-pyran-2-yloxy)octacosane-24-ol

: 915024-77-0
(2S)-1-(t-butyldiphenylsiloxy)-2-(p-methoxybenzyloxy)-24,28-di(tetrahydro-2H-pyran-2-yloxy)octacosane

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/ol062011o

Reference yield:

: 914936-39-3
(2S)-1-(t-butyldiphenylsiloxy)-4-iodo-2-(p-methoxybenzyloxy)butane

: 915024-77-0
(2S)-1-(t-butyldiphenylsiloxy)-2-(p-methoxybenzyloxy)-24,28-di(tetrahydro-2H-pyran-2-yloxy)octacosane

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / cuprous(I) iodide; 2,2'-bipyridyl / tetrahydrofuran / -20 - 20 °C

2: 96 percent / aq. HCl / tetrahydrofuran / 6 h / 20 °C

3: 92 percent / imidazole; triphenylphosphine; iodine / benzene / 0.5 h / 20 °C

4: 96 percent / cuprous(I) iodide; 2,2'-bipyridyl / tetrahydrofuran / -17 - 20 °C

5: 99 percent / aq. HCl / tetrahydrofuran / 6 h / 20 °C

6: 85 percent / PCC / CH₂Cl₂ / 22 h / 20 °C

7: 81 percent / tetrahydrofuran / 1.5 h / 0 °C

8: 86 percent / p-toluenesulfonic acid monohydrate / CH₂Cl₂ / 2 h / 20 °C

With 1H-imidazole; hydrogenchloride; [2,2]bipyridinyl; copper(l) iodide; iodine; toluene-4-sulfonic acid; triphenylphosphine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/ol062011o

Reference yield:

: 914936-43-9
(2S)-1-(t-butyldiphenylsiloxy)-14-iodo-2-(p-methoxybenzyloxy)tetradecane

: 915024-77-0
(2S)-1-(t-butyldiphenylsiloxy)-2-(p-methoxybenzyloxy)-24,28-di(tetrahydro-2H-pyran-2-yloxy)octacosane

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / cuprous(I) iodide; 2,2'-bipyridyl / tetrahydrofuran / -17 - 20 °C

2: 99 percent / aq. HCl / tetrahydrofuran / 6 h / 20 °C

3: 85 percent / PCC / CH₂Cl₂ / 22 h / 20 °C

4: 81 percent / tetrahydrofuran / 1.5 h / 0 °C

5: 86 percent / p-toluenesulfonic acid monohydrate / CH₂Cl₂ / 2 h / 20 °C

With hydrogenchloride; [2,2]bipyridinyl; copper(l) iodide; toluene-4-sulfonic acid; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol062011o