Benzyloxycarbonylamino-acetic acid (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-((2S,3R,4S,6R)-3-acetoxy-4-dimethylamino-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-12,13-dihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-4-yl ester

Base Information

Chemical Name:Benzyloxycarbonylamino-acetic acid (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-((2S,3R,4S,6R)-3-acetoxy-4-dimethylamino-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-12,13-dihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-4-yl ester
CAS No.:152235-62-6
Molecular Formula:C₄₂H₆₆N₂O₁₄
Molecular Weight:822.991
Hs Code.:

Benzyloxycarbonylamino-acetic acid (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-((2S,3R,4S,6R)-3-acetoxy-4-dimethylamino-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-12,13-dihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-4-yl ester

Synonyms:Benzyloxycarbonylamino-acetic acid (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-((2S,3R,4S,6R)-3-acetoxy-4-dimethylamino-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-12,13-dihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-4-yl ester

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Chemical Property of Benzyloxycarbonylamino-acetic acid (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-((2S,3R,4S,6R)-3-acetoxy-4-dimethylamino-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-12,13-dihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-4-yl ester

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Technology Process of Benzyloxycarbonylamino-acetic acid (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-((2S,3R,4S,6R)-3-acetoxy-4-dimethylamino-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-12,13-dihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-4-yl ester

There total 3 articles about Benzyloxycarbonylamino-acetic acid (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-((2S,3R,4S,6R)-3-acetoxy-4-dimethylamino-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-12,13-dihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1138-80-3
N-(Benzyloxycarbonyl)glycine

: 143353-81-5
3-Ode-[(2,6-dideoxy-3-methyl-3-O-methyl-α-L-ribohexopyranosyl)oxy]-6-O-methylerythromycin 2￠-acetate

: 152235-62-6
Benzyloxycarbonylamino-acetic acid (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-((2S,3R,4S,6R)-3-acetoxy-4-dimethylamino-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-12,13-dihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-4-yl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1021/jm015566s

Reference yield:

: 81103-11-9
clarithromycin

: 152235-62-6
Benzyloxycarbonylamino-acetic acid (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-((2S,3R,4S,6R)-3-acetoxy-4-dimethylamino-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-12,13-dihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-4-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 53 percent / hydrochloric acid / H₂O / 3 h / 20 °C

2: 96 percent / acetone / 6 h / 20 °C

3: EDC*HCl; DMAP / CH₂Cl₂ / 20 °C

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water; acetone;
DOI:10.1021/jm015566s

Reference yield:

: 118058-74-5
3-O-descladinosylclarithromycin

: 152235-62-6
Benzyloxycarbonylamino-acetic acid (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-((2S,3R,4S,6R)-3-acetoxy-4-dimethylamino-6-methyl-tetrahydro-pyran-2-yloxy)-14-ethyl-12,13-dihydroxy-7-methoxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-4-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / acetone / 6 h / 20 °C

2: EDC*HCl; DMAP / CH₂Cl₂ / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetone;
DOI:10.1021/jm015566s