1-[5-tert-butyl-2-(2-dimethylamino-ethyl)-2H-pyrazol-3-yl]-3-{(1S,4R)-4-[3-(2,6-dichloro-phenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea

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Chemical Name:1-[5-tert-butyl-2-(2-dimethylamino-ethyl)-2H-pyrazol-3-yl]-3-{(1S,4R)-4-[3-(2,6-dichloro-phenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea
CAS No.:1443247-43-5
Molecular Formula:C₃₄H₃₈Cl₂N₈O₂
Molecular Weight:661.634
Hs Code.:

1-[5-tert-butyl-2-(2-dimethylamino-ethyl)-2H-pyrazol-3-yl]-3-{(1S,4R)-4-[3-(2,6-dichloro-phenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea

Synonyms:1-[5-tert-butyl-2-(2-dimethylamino-ethyl)-2H-pyrazol-3-yl]-3-{(1S,4R)-4-[3-(2,6-dichloro-phenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea

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Chemical Property of 1-[5-tert-butyl-2-(2-dimethylamino-ethyl)-2H-pyrazol-3-yl]-3-{(1S,4R)-4-[3-(2,6-dichloro-phenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea

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Technology Process of 1-[5-tert-butyl-2-(2-dimethylamino-ethyl)-2H-pyrazol-3-yl]-3-{(1S,4R)-4-[3-(2,6-dichloro-phenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea

There total 15 articles about 1-[5-tert-butyl-2-(2-dimethylamino-ethyl)-2H-pyrazol-3-yl]-3-{(1S,4R)-4-[3-(2,6-dichloro-phenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1443248-66-5
methanesulfonic acid 2-[3-tert-butyl-5-(3-{(1S,4R)-4-[3-(2,6-dichloro-phenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-ureido)-pyrazol-1-yl]-ethyl ester

: 124-40-3
dimethyl amine

: 1443247-43-5
1-[5-tert-butyl-2-(2-dimethylamino-ethyl)-2H-pyrazol-3-yl]-3-{(1S,4R)-4-[3-(2,6-dichloro-phenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea

Guidance literature:: In tetrahydrofuran; at 60 ℃; for 18h; Inert atmosphere;

Reference yield:

: 908267-36-7
2-(5-amino-3-(tert-butyl)-1H-pyrazol-1-yl)ethanol

: 1443247-43-5
1-[5-tert-butyl-2-(2-dimethylamino-ethyl)-2H-pyrazol-3-yl]-3-{(1S,4R)-4-[3-(2,6-dichloro-phenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / water; ethyl acetate / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 114 h / 20 - 60 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.58 h / 20 °C

4: tetrahydrofuran / 18 h / 60 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate;

Reference yield:

: 1443248-60-9
2,6-dichloro-benzoic acid N'-(5-fluoro-pyridin-2-yl)-hydrazide

: 1443247-43-5
1-[5-tert-butyl-2-(2-dimethylamino-ethyl)-2H-pyrazol-3-yl]-3-{(1S,4R)-4-[3-(2,6-dichloro-phenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; hexachloroethane; triethylamine / tetrahydrofuran / 90 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

2.2: 1 h / 60 °C

3.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 114 h / 20 - 60 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.58 h / 20 °C

5.1: tetrahydrofuran / 18 h / 60 °C / Inert atmosphere

With hexachloroethane; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; mineral oil;