2-(biphenyl-4-yl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole

Base Information

• Chemical Name: 2-(biphenyl-4-yl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole
• CAS No.: 1394893-14-1
• Molecular Formula: C₂₂H₁₄FN₃S
• Molecular Weight: 371.438
• Mol file: 1394893-14-1.mol

Synonyms:2-(biphenyl-4-yl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole

Chemical Property of 2-(biphenyl-4-yl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(biphenyl-4-yl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole

There total 2 articles about 2-(biphenyl-4-yl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

5-([1,1'-biphenyl]-4-yl)-1,3,4-thiadiazol-2-amine (70057-66-8) + 2-bromo-4'-fluoroacetophenone (403-29-2) → 2-(biphenyl-4-yl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole (1394893-14-1)

Guidance literature:

With N,N-dimethyl-formamide; In ethanol; Reflux;

DOI:10.1016/j.ejmech.2012.08.012

Reference yield:

biphenyl-4-carboxylic acid (92-92-2) → 2-(biphenyl-4-yl)-6-(4-fluorophenyl)imidazo[2,1-b][1,3,4]thiadiazole (1394893-14-1)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate

2: N,N-dimethyl-formamide / ethanol / Reflux

With N,N-dimethyl-formamide; trichlorophosphate; In ethanol;

DOI:10.1016/j.ejmech.2012.08.012

upstream raw materials:

biphenyl-4-carboxylic acid

5-([1,1'-biphenyl]-4-yl)-1,3,4-thiadiazol-2-amine

2-bromo-4'-fluoroacetophenone