(R)-N-((S)-1-(4-bromophenyl)ethyl)-3,5-dihydroxy-5-methyl-3-phenylhexanamide

Base Information

Chemical Name:(R)-N-((S)-1-(4-bromophenyl)ethyl)-3,5-dihydroxy-5-methyl-3-phenylhexanamide
CAS No.:1383540-71-3
Molecular Formula:C₂₁H₂₆BrNO₃
Molecular Weight:420.346
Hs Code.:

Synonyms:(R)-N-((S)-1-(4-bromophenyl)ethyl)-3,5-dihydroxy-5-methyl-3-phenylhexanamide

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Chemical Property of (R)-N-((S)-1-(4-bromophenyl)ethyl)-3,5-dihydroxy-5-methyl-3-phenylhexanamide

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Technology Process of (R)-N-((S)-1-(4-bromophenyl)ethyl)-3,5-dihydroxy-5-methyl-3-phenylhexanamide

There total 4 articles about (R)-N-((S)-1-(4-bromophenyl)ethyl)-3,5-dihydroxy-5-methyl-3-phenylhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.1%

: 1383540-79-1
(S)-2-bromo-N-(1-(4-bromophenyl)ethyl)acetamide

: 144741-40-2
3-methyl-1-phenyl-3-(trimethylsilyloxy)butan-1-one

: 1383540-71-3
(R)-N-((S)-1-(4-bromophenyl)ethyl)-3,5-dihydroxy-5-methyl-3-phenylhexanamide

Guidance literature:: (S)-2-bromo-N-(1-(4-bromophenyl)ethyl)acetamide; 3-methyl-1-phenyl-3-(trimethylsilyloxy)butan-1-one; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; diethylzinc; In 1,2-dimethoxyethane; at -20 - 0 ℃; Inert atmosphere;

With hydrogenchloride; water; In 1,2-dimethoxyethane; for 0.25h;

Reference yield:

: 43108-74-3
3-hydroxy-3-methyl-1-phenyl-1-butanone

: 1383540-71-3
(R)-N-((S)-1-(4-bromophenyl)ethyl)-3,5-dihydroxy-5-methyl-3-phenylhexanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 25 - 35 °C

2.1: 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; diethylzinc / 1,2-dimethoxyethane / -20 - 0 °C / Inert atmosphere

2.2: 0.25 h

With 1H-imidazole; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; diethylzinc; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;

Reference yield:

: 27298-97-1
(S)-1-(4-bromophenyl)ethylamine

: 1383540-71-3
(R)-N-((S)-1-(4-bromophenyl)ethyl)-3,5-dihydroxy-5-methyl-3-phenylhexanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / toluene; water / 1 h / 5 - 25 °C

2.1: 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; diethylzinc / 1,2-dimethoxyethane / -20 - 0 °C / Inert atmosphere

2.2: 0.25 h

With sodium hydroxide; 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; diethylzinc; In 1,2-dimethoxyethane; water; toluene;