4-(N-((2-(trimethylsilyl)ethoxy)carbonyl)amino)tetrafluorophenyl azide

Base Information

Chemical Name:4-(N-((2-(trimethylsilyl)ethoxy)carbonyl)amino)tetrafluorophenyl azide
CAS No.:294187-77-2
Molecular Formula:C₁₂H₁₄F₄N₄O₂Si
Molecular Weight:350.348
Hs Code.:

Synonyms:4-(N-((2-(trimethylsilyl)ethoxy)carbonyl)amino)tetrafluorophenyl azide

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Chemical Property of 4-(N-((2-(trimethylsilyl)ethoxy)carbonyl)amino)tetrafluorophenyl azide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:: SDS file from LookChem

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Technology Process of 4-(N-((2-(trimethylsilyl)ethoxy)carbonyl)amino)tetrafluorophenyl azide

There total 5 articles about 4-(N-((2-(trimethylsilyl)ethoxy)carbonyl)amino)tetrafluorophenyl azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 345976-51-4
4-azido-2,3,5,6-tetrafluoro-benzoyl azide

: 294187-77-2
4-(N-((2-(trimethylsilyl)ethoxy)carbonyl)amino)tetrafluorophenyl azide

Guidance literature:: In benzene; at 70 ℃; for 7h;
DOI:10.1021/jo000402p

Reference yield:

: 36629-42-2
methyl pentafluorobenzoate

: 294187-77-2
4-(N-((2-(trimethylsilyl)ethoxy)carbonyl)amino)tetrafluorophenyl azide

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / NaN₃ / acetone; H₂O / 16 h / Heating

2: 98 percent / aq. NaOH / methanol / 25 °C

3: 100 percent / PCl₅ / diethyl ether / 1 h / 20 °C

4: sodium azide / acetone; H₂O / 0.25 h / 0 °C

5: 92 percent / benzene / 7 h / 70 °C

With sodium hydroxide; sodium azide; phosphorus pentachloride; In methanol; diethyl ether; water; acetone; benzene; 1: Substitution / 2: Hydrolysis / 3: Substitution / 4: Substitution / 5: Rearrangement;
DOI:10.1021/jo000402p

Reference yield:

: 122590-75-4
methyl 4-azidotetrafluorobenzoate

: 294187-77-2
4-(N-((2-(trimethylsilyl)ethoxy)carbonyl)amino)tetrafluorophenyl azide

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / aq. NaOH / methanol / 25 °C

2: 100 percent / PCl₅ / diethyl ether / 1 h / 20 °C

3: sodium azide / acetone; H₂O / 0.25 h / 0 °C

4: 92 percent / benzene / 7 h / 70 °C

With sodium hydroxide; sodium azide; phosphorus pentachloride; In methanol; diethyl ether; water; acetone; benzene; 1: Hydrolysis / 2: Substitution / 3: Substitution / 4: Rearrangement;
DOI:10.1021/jo000402p