Tert-butyloxycarbonyl-O-tert-butyloxycarbonyl-L-tyrosyl-D-alanyl-glycine p-nitrophenyl ester

Base Information

Chemical Name:Tert-butyloxycarbonyl-O-tert-butyloxycarbonyl-L-tyrosyl-D-alanyl-glycine p-nitrophenyl ester
CAS No.:126399-13-1
Molecular Formula:C₃₀H₃₈N₄O₁₁
Molecular Weight:630.652
Hs Code.:

Synonyms:Tert-butyloxycarbonyl-O-tert-butyloxycarbonyl-L-tyrosyl-D-alanyl-glycine p-nitrophenyl ester

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Chemical Property of Tert-butyloxycarbonyl-O-tert-butyloxycarbonyl-L-tyrosyl-D-alanyl-glycine p-nitrophenyl ester

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Technology Process of Tert-butyloxycarbonyl-O-tert-butyloxycarbonyl-L-tyrosyl-D-alanyl-glycine p-nitrophenyl ester

There total 3 articles about Tert-butyloxycarbonyl-O-tert-butyloxycarbonyl-L-tyrosyl-D-alanyl-glycine p-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: Boc₂-Tyr-Ala-Gly(OBzl)

: 126399-13-1
Tert-butyloxycarbonyl-O-tert-butyloxycarbonyl-L-tyrosyl-D-alanyl-glycine p-nitrophenyl ester

Guidance literature:: Boc₂-Tyr-Ala-Gly(OBzl); With palladium on activated charcoal; hydrogen; In ethanol; at 43 ℃; for 3h; Large scale;

4-nitro-phenol; With dicyclohexyl-carbodiimide; In ethyl acetate; N,N-dimethyl-formamide; at -18 - 20 ℃; for 24h; Large scale;

Reference yield:

: 64410-44-2
N-(tert-butoxycarbonyl)-D-alanylglycine benzyl ester

: 126399-13-1
Tert-butyloxycarbonyl-O-tert-butyloxycarbonyl-L-tyrosyl-D-alanyl-glycine p-nitrophenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / 1.5 h / 5 - 20 °C

2.1: N,N-dimethyl-formamide / 12 h / 25 °C / pH 7.2 - 7.4

3.1: palladium on activated charcoal; hydrogen / ethanol / 3 h / 43 °C / Large scale

3.2: 24 h / -18 - 20 °C / Large scale

With palladium on activated charcoal; hydrogen; trifluoroacetic acid; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 70663-49-9
H-Ala-Gly(OBzl)

: 126399-13-1
Tert-butyloxycarbonyl-O-tert-butyloxycarbonyl-L-tyrosyl-D-alanyl-glycine p-nitrophenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide / 12 h / 25 °C / pH 7.2 - 7.4

2.1: palladium on activated charcoal; hydrogen / ethanol / 3 h / 43 °C / Large scale

2.2: 24 h / -18 - 20 °C / Large scale

With palladium on activated charcoal; hydrogen; In ethanol; N,N-dimethyl-formamide;