[(3,5-bis{(3,5-bis-(prop-2-ynylcarbamoyl)phenylcarbamoyl)methylcarbamoyl}phenylcarbamoyl)methyl]-carbamic acid benzyl ester

Base Information

Chemical Name:[(3,5-bis{(3,5-bis-(prop-2-ynylcarbamoyl)phenylcarbamoyl)methylcarbamoyl}phenylcarbamoyl)methyl]-carbamic acid benzyl ester
CAS No.:940005-75-4
Molecular Formula:C₅₀H₄₄N₁₀O₁₁
Molecular Weight:960.96
Hs Code.:

Synonyms:[(3,5-bis{(3,5-bis-(prop-2-ynylcarbamoyl)phenylcarbamoyl)methylcarbamoyl}phenylcarbamoyl)methyl]-carbamic acid benzyl ester

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Chemical Property of [(3,5-bis{(3,5-bis-(prop-2-ynylcarbamoyl)phenylcarbamoyl)methylcarbamoyl}phenylcarbamoyl)methyl]-carbamic acid benzyl ester

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Technology Process of [(3,5-bis{(3,5-bis-(prop-2-ynylcarbamoyl)phenylcarbamoyl)methylcarbamoyl}phenylcarbamoyl)methyl]-carbamic acid benzyl ester

There total 8 articles about [(3,5-bis{(3,5-bis-(prop-2-ynylcarbamoyl)phenylcarbamoyl)methylcarbamoyl}phenylcarbamoyl)methyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 852355-43-2
5-(2-((2-oxo-2-phenyl-1λ²-ethyl)amino)acetamido)isophthalic acid

: 940005-74-3
5-(2-amino-acethylamino)-N,N'-di(prop-2-ynyl)isophthalamide

: 940005-75-4
[(3,5-bis{(3,5-bis-(prop-2-ynylcarbamoyl)phenylcarbamoyl)methylcarbamoyl}phenylcarbamoyl)methyl]-carbamic acid benzyl ester

Guidance literature:: 5-(2-((2-oxo-2-phenyl-1λ²-ethyl)amino)acetamido)isophthalic acid; With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In tetrahydrofuran; at 0 ℃; for 12h;

5-(2-amino-acethylamino)-N,N'-di(prop-2-ynyl)isophthalamide; With 4-methyl-morpholine; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃; for 20h; Further stages.;
DOI:10.1016/j.bmcl.2007.02.028

Reference yield:

: 99-31-0
5-aminoisophthalic acid

: 940005-75-4
[(3,5-bis{(3,5-bis-(prop-2-ynylcarbamoyl)phenylcarbamoyl)methylcarbamoyl}phenylcarbamoyl)methyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 67 percent / NaOH / dimethylformamide; H₂O / 30 h / 0 - 20 °C

2.1: 2-chloro-4,6-dimethoxy-1,3,5-triazine; N-methylmorpholine / tetrahydrofuran / 0 °C

2.2: 85 percent / N-methylmorpholine / dimethylformamide; tetrahydrofuran / 20 h / 0 - 20 °C

3.1: 80 percent / trifluoroacetic acid; triisopropylsilane / CH₂Cl₂ / 8 h / 20 °C

4.1: 96 percent / Na₂CO₃ / acetonitrile / 20 °C

5.1: 81 percent / NH₃ / methanol / 6 h / 20 °C

6.1: 2-chloro-4,6-dimethoxy-1,3,5-triazine; N-methylmorpholine / tetrahydrofuran / 12 h / 0 °C

6.2: 78 percent / N-methylmorpholine / tetrahydrofuran; dimethylformamide / 20 h / 0 - 20 °C

With 4-methyl-morpholine; sodium hydroxide; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; chlorotriisopropylsilane; ammonia; sodium carbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2007.02.028

Reference yield:

: 61389-11-5
3,5-dicarboxyphenyl chloroacetamide

: 940005-75-4
[(3,5-bis{(3,5-bis-(prop-2-ynylcarbamoyl)phenylcarbamoyl)methylcarbamoyl}phenylcarbamoyl)methyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 91 percent / aq. NH₃ / 12 h / 20 °C

2.1: 79 percent / NaHCO₃ / 12 h / 20 °C

3.1: 2-chloro-4,6-dimethoxy-1,3,5-triazine; N-methylmorpholine / tetrahydrofuran / 12 h / 0 °C

3.2: 78 percent / N-methylmorpholine / tetrahydrofuran; dimethylformamide / 20 h / 0 - 20 °C

With 4-methyl-morpholine; ammonium hydroxide; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; sodium hydrogencarbonate; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2007.02.028