2-tert-butoxycarbonylamino-3-[(diphenylphosphanyl)-methylsulfanylcarbonyl]-propionic acid benzyl ester

Base Information

Chemical Name:2-tert-butoxycarbonylamino-3-[(diphenylphosphanyl)-methylsulfanylcarbonyl]-propionic acid benzyl ester
CAS No.:812697-72-6
Molecular Formula:C₂₉H₃₂NO₅PS
Molecular Weight:537.617
Hs Code.:

2-<i>tert</i>-butoxycarbonylamino-3-[(diphenylphosphanyl)-methylsulfanylcarbonyl]-propionic acid benzyl ester

Synonyms:2-tert-butoxycarbonylamino-3-[(diphenylphosphanyl)-methylsulfanylcarbonyl]-propionic acid benzyl ester

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Chemical Property of 2-tert-butoxycarbonylamino-3-[(diphenylphosphanyl)-methylsulfanylcarbonyl]-propionic acid benzyl ester

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Technology Process of 2-tert-butoxycarbonylamino-3-[(diphenylphosphanyl)-methylsulfanylcarbonyl]-propionic acid benzyl ester

There total 6 articles about 2-tert-butoxycarbonylamino-3-[(diphenylphosphanyl)-methylsulfanylcarbonyl]-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: C₂₉H₃₅BNO₅PS

: 812697-72-6
2-tert-butoxycarbonylamino-3-[(diphenylphosphanyl)-methylsulfanylcarbonyl]-propionic acid benzyl ester

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; In toluene; for 1h; Heating;
DOI:10.1021/ol048271s

Reference yield:

: 446822-71-5
(borane)diphenylphosphinomethanethiol acetate

: 812697-72-6
2-tert-butoxycarbonylamino-3-[(diphenylphosphanyl)-methylsulfanylcarbonyl]-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaOCH₃ / methanol / 0.17 h

2: 3.3 g / DCC; DMAP / CH₂Cl₂ / 4 h

3: 91 percent / DABCO / toluene / 1 h / Heating

With 1,4-diaza-bicyclo[2.2.2]octane; dmap; sodium methylate; dicyclohexyl-carbodiimide; In methanol; dichloromethane; toluene;
DOI:10.1021/ol048271s

Reference yield:

: 127686-81-1
hydroxymethyl(diphenyl)phosphine borane complex

: 812697-72-6
2-tert-butoxycarbonylamino-3-[(diphenylphosphanyl)-methylsulfanylcarbonyl]-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / Et₃N / CH₂Cl₂ / 15 h / 0 °C

2: 65 percent / Cs₂CO₃ / dimethylformamide / 8 h / -20 - 20 °C

3: NaOCH₃ / methanol / 0.17 h

4: 3.3 g / DCC; DMAP / CH₂Cl₂ / 4 h

5: 91 percent / DABCO / toluene / 1 h / Heating

With 1,4-diaza-bicyclo[2.2.2]octane; dmap; sodium methylate; caesium carbonate; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol048271s