1-(2,2-difluoroethyl)-1H-pyrazol-4-amine

Base Information

Chemical Name:1-(2,2-difluoroethyl)-1H-pyrazol-4-amine
CAS No.:1006333-08-9
Molecular Formula:C₅H₇F₂N₃
Molecular Weight:147.127
Hs Code.:
European Community (EC) Number:817-730-8
Nikkaji Number:J2.579.644F
Mol file:1006333-08-9.mol

Synonyms:1006333-08-9;1-(2,2-difluoroethyl)-1H-pyrazol-4-amine;1-(2,2-difluoroethyl)pyrazol-4-amine;1-(2,2-Difluoroethyl)-1H-pyrazol-4-ylamine;1H-Pyrazol-4-amine, 1-(2,2-difluoroethyl)-;MFCD08558974;SCHEMBL1662503;STK352600;AKOS000313850;BS-13183;SY042686;DB-179785;CS-0155483;EN300-79410;1-(2,2-Difluoro-ethyl)-1H-pyrazol-4-ylamine;A1-03682

Suppliers and Price of 1-(2,2-difluoroethyl)-1H-pyrazol-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(2,2-Difluoroethyl)-1H-pyrazol-4-amine
250mg
$ 185.00

TRC
1-(2,2-Difluoroethyl)-1H-pyrazol-4-amine
100mg
$ 130.00

TRC
1-(2,2-Difluoroethyl)-1H-pyrazol-4-amine
1g
$ 475.00

Matrix Scientific
1-(2,2-Difluoroethyl)-1H-pyrazol-4-ylamine 95%
5g
$ 1663.00

Crysdot
1-(2,2-Difluoroethyl)-1H-pyrazol-4-aminehydrochloride 97%
1g
$ 400.00

CHESS?
KK001806:1-(2,2-difluoroethyl)-1H-pyrazol-4-amine,hydrochloride 95
5 g
$ 1680.00

CHESS?
KK001806:1-(2,2-difluoroethyl)-1H-pyrazol-4-amine,hydrochloride 95
1 g
$ 660.00

Ambeed
1-(2,2-Difluoroethyl)-1H-pyrazol-4-amine 97%
250mg
$ 92.00

Ambeed
1-(2,2-Difluoroethyl)-1H-pyrazol-4-amine 97%
100mg
$ 55.00

Ambeed
1-(2,2-Difluoroethyl)-1H-pyrazol-4-amine 97%
1g
$ 219.00

Total 7 raw suppliers

Chemical Property of 1-(2,2-difluoroethyl)-1H-pyrazol-4-amine

Chemical Property:

XLogP3:0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:147.06080356
Heavy Atom Count:10
Complexity:109

Purity/Quality:

99%, ^*data from raw suppliers

1-(2,2-Difluoroethyl)-1H-pyrazol-4-amine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=C(C=NN1CC(F)F)N
Uses 1-(2,2-Difluoroethyl)-1H-pyrazol-4-amine acts as a reagent for the development of pyrimidine derivatives as JAK3 inhibitors.

Technology Process of 1-(2,2-difluoroethyl)-1H-pyrazol-4-amine

There total 4 articles about 1-(2,2-difluoroethyl)-1H-pyrazol-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1006442-51-8
1-(2,2-difluoroethyl)-4-nitro-1H-pyrazole

: 1006333-08-9
1-(2,2-difluoroethyl)-1H-pyrazol-4-ylamine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 3h; under 775.743 Torr;

Reference yield:

: 2075-46-9
4-nitro-1H-pyrazole

: 163035-65-2
methanesulfonic acid 2,2-difluoroethyl ester

: 1006333-08-9
1-(2,2-difluoroethyl)-1H-pyrazol-4-ylamine

Guidance literature:: 4-nitro-1H-pyrazole; methanesulfonic acid 2,2-difluoroethyl ester; With potassium carbonate; In acetonitrile; at 60 ℃; for 18h;

With hydrogen; palladium 10% on activated carbon; In methanol; for 18h;

Reference yield:

: 2075-46-9
4-nitro-1H-pyrazole

: 598-39-0
1,1-difluoro-2-iodoethane

: 1006333-08-9
1-(2,2-difluoroethyl)-1H-pyrazol-4-ylamine

Guidance literature:: 4-nitro-1H-pyrazole; 1,1-difluoro-2-iodoethane; With potassium carbonate; In acetonitrile; at 70 ℃; for 1h;

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2h;