163035-65-2

Usage

Uses

Used in Pharmaceutical Industry:
2,2-Difluoroethyl mesylate is used as a reagent for the synthesis of pharmaceuticals and other organic compounds, particularly in the development of fluorinated products. Its reactivity allows for the formation of various chemical bonds, making it a valuable component in the creation of new drugs and therapeutic agents.
Used in Organic Synthesis:
2,2-Difluoroethyl mesylate is used as an alkylating agent in organic synthesis for the formation of carbon-carbon, carbon-oxygen, and carbon-nitrogen bonds. Its ability to react with nucleophiles such as amines, alcohols, and thiols makes it a versatile compound in the synthesis of a wide range of organic molecules.
Safety Precautions:
Due to its reactivity and potential for harmful effects, proper safety precautions and handling procedures should be followed when working with 2,2-Difluoroethyl mesylate. This includes the use of appropriate personal protective equipment, working in a well-ventilated area, and following established guidelines for the safe handling and disposal of hazardous chemicals.

Upstream product

• 359-13-7 difluoroethanol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 924647-38-1 1-(2,2-difluoroethoxy)-2-(propylsulphanyl)-3-(trifluoromethyl)benzene 
• 1160246-19-4 2-(2,2-difluoroethoxy)benzonitrile 
• 1006333-08-9 1-(2,2-difluoroethyl)-1H-pyrazol-4-ylamine 
• 864642-82-0 1-bromo-3,5-dichloro-2-(2,2-difluoroethoxy)benzene 
• 1174185-60-4 5-amino-6-(2,3,5-trichlorophenyl)-2,3-dihydro-3-imino-2-(2,2-difluoroethyl)-1,2,4-triazine 
• 433938-89-7 3-chloro-5-(2,2-difluoroethoxy)benzaldehyde 

Relevant academic research and scientific papers

A 2 - (2, 2 - two fluorine ethoxy groups) -6 - trifluoromethyl phenyl propyl sulfide preparation method (by machine translation)

The invention relates to the field of organic synthesis, in particular relates to a 2 - (2, 2 - two fluorine ethoxy groups) - 6 - trifluoromethyl phenyl propyl sulfide preparation method, including difluoro ethanol as the raw material, under the action of

1,2,4-oxadiazole insecticide containing o-sulfonylbenzoylimino group

The invention discloses a 1,2,4-oxadiazole compound containing an o-sulfonylbenzoylimino group. The compound has a general structural formula as shown in a formula I which is described in the specification. In the formula I, R is selected from a 2,2-difluoroethyl group or an ethyl group. The compound as shown in the formula I has excellent insecticidal activity and certain bactericidal action, andcan be used for prevention and treatment of agricultural or forestal plant pests and diseases.

2-(2 ', 2'-difluoro-ethoxy)-6-trifluoromethyl-phenylpropyl sulfur ether synthesis process

The present invention discloses a 2-(2 ', 2'-difluoro-ethoxy)-6-trifluoromethyl-phenylpropyl sulfur ether synthesis process. The process is as follows: 2-propyl mercapto-3-trifluoromehtyl phenol, 2,2-difluoroethanol and methanesulfonyl chloride are used a

Preparation method of 2-(2',2'-difluoroethoxy)-6-(trifluoromethyl)benzene-1-sulfonyl chloride

The invention discloses a preparation method of 2-(2',2'-difluoroethoxy)-6-(trifluoromethyl)benzene-1-sulfonyl chloride. The preparation method comprises following steps: (1) a sulfonyl chloride or a sulfonic anhydride is added into an organic solvent containing 2,2-difluoroethanol and an alkali, and a compound I is obtained via complete reaction, wherein the sulfonyl chloride is selected from alkyl sulfonyl chloride or benzene sulfonyl chloride, and the sulfonic anhydride is selected from alkyl sulfonic anhydride or benzene sulfonic anhydride; (2) m-trifluoromethylphenol, the compound I, and an alkali are added into an organic solvent, an obtained mixture is heated and stirred, and a compound II is obtained via complete reaction; and (3) an accelerant and the compound II are added into an organic solvent, a strong alkali is added, the sulfonyl chloride is added into an obtained reaction solution, and 2-(2',2'-difluoroethoxy)-6-(trifluoromethyl)benzene-1-sulfonyl chloride is obtained via complete reaction and purifying. The preparation method is simple, is high in efficiency, is safe and reliable, and is capable of increasing synthesis efficiency of penoxsulam greatly; and operation is simple and convenient.

NEW ARYL-BENZOCYCLOALKYL AMIDE DERIVATIVES

The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1, A2 and n are as described herein, compositions including the compounds and methods of using the compounds.

NEW BIARYL AMIDE DERIVATIVES

The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and A are as described herein, compositions including the compounds and methods of using the compounds.

NEW BIARYL AMIDE DERIVATIVES

The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and A are as described herein, compositions including the compounds and methods of using the compounds.

NEW ARYL-BENZOCYCLOALKYL AMIDE DERIVATIVES

The invention provides novel compounds having the general Formula (I), wherein R1, R2, R3, R4 R5, R6, R7, R8 R9, R10, R11, R12, A1, A2 and n are as described herein, compositions including the compounds and methods of using the compounds.

HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS

The present invention relates to compounds of formula (I) wherein X1 to X5, Y, Z1 to Z3, and R have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.

PYRAZOLE COMPOUNDS AS JAK INHIBITORS

The present invention relates to compounds of formula (I), wherein R1, R2, R1a, R1b have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.