2,4-difluoro-N-(2-methoxy-5-(3-(prop-1-yn-1-yl)pyrazolo[1,5-a]pyrimidin-5-yl)pyridin-3-yl)benzenesulfonamide

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Chemical Name:2,4-difluoro-N-(2-methoxy-5-(3-(prop-1-yn-1-yl)pyrazolo[1,5-a]pyrimidin-5-yl)pyridin-3-yl)benzenesulfonamide
CAS No.:1621718-50-0
Molecular Formula:C₂₁H₁₅F₂N₅O₃S
Molecular Weight:455.445
Hs Code.:

Synonyms:2,4-difluoro-N-(2-methoxy-5-(3-(prop-1-yn-1-yl)pyrazolo[1,5-a]pyrimidin-5-yl)pyridin-3-yl)benzenesulfonamide

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Chemical Property of 2,4-difluoro-N-(2-methoxy-5-(3-(prop-1-yn-1-yl)pyrazolo[1,5-a]pyrimidin-5-yl)pyridin-3-yl)benzenesulfonamide

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Technology Process of 2,4-difluoro-N-(2-methoxy-5-(3-(prop-1-yn-1-yl)pyrazolo[1,5-a]pyrimidin-5-yl)pyridin-3-yl)benzenesulfonamide

There total 7 articles about 2,4-difluoro-N-(2-methoxy-5-(3-(prop-1-yn-1-yl)pyrazolo[1,5-a]pyrimidin-5-yl)pyridin-3-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.52%

: 1621718-78-2
2,4-difluoro-N-(5-(3-iodopyrazolo[1,5-a]pyrimidin-5-yl)-2-methoxypyridin-3-yl)benzenesulfonamide

: 74-99-7
prop-1-yne

: 1621718-50-0
2,4-difluoro-N-(2-methoxy-5-(3-(prop-1-yn-1-yl)pyrazolo[1,5-a]pyrimidin-5-yl)pyridin-3-yl)benzenesulfonamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 45 ℃; for 10h; Inert atmosphere;

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 1621718-50-0
2,4-difluoro-N-(2-methoxy-5-(3-(prop-1-yn-1-yl)pyrazolo[1,5-a]pyrimidin-5-yl)pyridin-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: methanol / 19 h / 0 - 20 °C

2.1: iron; ammonium chloride; ethanol / water / 1 h / Reflux

3.1: pyridine / 19 h / 0 - 20 °C

3.2: 12 h / 20 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 7 h / 90 °C / Inert atmosphere

5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; 1,2-dimethoxyethane / 20 °C / Inert atmosphere

5.2: 6 h / 100 °C / Inert atmosphere

6.1: N-iodo-succinimide / methanol / 10 h / 45 °C

7.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 10 h / 45 °C / Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ethanol; potassium acetate; iron; sodium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

: 884495-39-0
5-bromo-2-(methyloxy)-3-pyridinamine

: 1621718-50-0
2,4-difluoro-N-(2-methoxy-5-(3-(prop-1-yn-1-yl)pyrazolo[1,5-a]pyrimidin-5-yl)pyridin-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / 19 h / 0 - 20 °C

1.2: 12 h / 20 °C

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 7 h / 90 °C / Inert atmosphere

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; 1,2-dimethoxyethane / 20 °C / Inert atmosphere

3.2: 6 h / 100 °C / Inert atmosphere

4.1: N-iodo-succinimide / methanol / 10 h / 45 °C

5.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 10 h / 45 °C / Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;