C₄₁H₃₆F₇NO₆

Base Information

• Chemical Name: C₄₁H₃₆F₇NO₆
• CAS No.: 960364-46-9
• Molecular Formula: C₄₁H₃₆F₇NO₆
• Molecular Weight: 771.729
• Mol file: 960364-46-9.mol

Synonyms:C₄₁H₃₆F₇NO₆

Chemical Property of C₄₁H₃₆F₇NO₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₁H₃₆F₇NO₆

There total 14 articles about C₄₁H₃₆F₇NO₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5R)-5-(((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentan-1-yl)-1-benzyloxycarbonylpyrrolidin-2-one + benzyl chloroformate (501-53-1,94274-21-2) → C41H36F7NO6 (960364-46-9)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; at -25 - 0 ℃; for 0.833333h; Cooling with methanol-dry ice-ice;

Reference yield:

1,3-cyclopentadione (3859-41-4) → C41H36F7NO6 (960364-46-9)

Guidance literature:

Multi-step reaction with 15 steps

1.1: potassium phosphate; johnphos / palladium diacetate / tetrahydrofuran / 12 h / 100 °C

2.1: disodium hydrogenphosphate / acetonitrile

2.2: 1.5 h / 65 °C

2.3: 0.5 h / pH < 8

3.1: 5% palladium over charcoal / ISOPROPYLAMIDE

3.2: 60 °C / 517.16 Torr

4.1: (R)-methyl oxazaborolidine; dimethylsulfide borane complex / toluene / 2.5 h / -20 °C

4.3: 20 °C

5.1: tetrahydrofuran; toluene / 0.75 h / -48 °C

5.2: 2.5 h / -25 °C

6.1: sulfuric acid / water / 3 h / 20 °C / Heating / reflux

7.1: tetrafluoroboric acid / n-heptane; dichloromethane / 23 h / -8 °C

8.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.58 h / 0 - 20 °C

10.1: tetrahydrofuran / 2.5 h / 0 - 20 °C

11.1: ammonium acetate; ammonia / methanol / 1 h / 20 °C

11.2: 16.5 h / 20 °C

12.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 0 - 20 °C

13.1: ozone / methanol / -70 - 0 °C / Cooling with acetone-dry ice

14.1: Jones reagent / acetone / 1 - 2 h / 20 - 30 °C

15.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.83 h / -25 - 0 °C / Cooling with methanol-dry ice-ice

With potassium phosphate; disodium hydrogenphosphate; Jones reagent; oxalyl dichloride; (R)-methyl oxazaborolidine; dimethylsulfide borane complex; sulfuric acid; ammonium acetate; ammonia; sodium hexamethyldisilazane; ozone; N-ethyl-N,N-diisopropylamine; johnphos; palladium diacetate; tetrafluoroboric acid; 5% palladium over charcoal; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; n-heptane; dichloromethane; ISOPROPYLAMIDE; water; acetone; toluene; acetonitrile;

Reference yield:

((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentane-carboxylic acid (405512-86-9) → C41H36F7NO6 (960364-46-9)

Guidance literature:

Multi-step reaction with 8 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.58 h / 0 - 20 °C

3.1: tetrahydrofuran / 2.5 h / 0 - 20 °C

4.1: ammonium acetate; ammonia / methanol / 1 h / 20 °C

4.2: 16.5 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 0 - 20 °C

6.1: ozone / methanol / -70 - 0 °C / Cooling with acetone-dry ice

7.1: Jones reagent / acetone / 1 - 2 h / 20 - 30 °C

8.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.83 h / -25 - 0 °C / Cooling with methanol-dry ice-ice

With Jones reagent; oxalyl dichloride; ammonium acetate; ammonia; sodium hexamethyldisilazane; ozone; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; acetone;

upstream raw materials:

benzyl chloroformate

((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentane-carboxylic acid

1,3-cyclopentadione

((1S),(2R),(3R))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)-ethoxy)-2-(4-fluorophenyl)-3-(1-oxopent-4-en-1-yl)cyclopentane

Downstream raw materials:

(3R,5R)-5-(((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentan-1-yl)-1,3-dibenzyloxycarbonyl-3-methylpyrrolidin-2-one

(3R,5R)-5-(((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentan-1-yl)-3-carboxy-3-methylpyrrolidin-2-one