(2S,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidin-2-one

Base Information

• Chemical Name: (2S,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidin-2-one
• CAS No.: 54750-13-9
• Molecular Formula: C₁₀H₁₃ClNO₂P
• Molecular Weight: 245.645

Synonyms:(2S,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidin-2-one

Chemical Property of (2S,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidin-2-one

Chemical Property:

Purity/Quality:

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Technology Process of (2S,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidin-2-one

There total 7 articles about (2S,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ephedrine hydrochloride (50-98-6) → (2S,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidin-2-one (54750-13-9) + (2R,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidin-2-one (54750-12-8)

Guidance literature:

With trichlorophosphate; In benzene; at -10 ℃; for 6h;

DOI:10.1021/jo971868j

Reference yield: 30.0%

(-)-ephedrine hydrochloride (50-98-6,134-71-4,345-78-8,670-40-6,24221-86-1,56979-55-6,63991-26-4,77262-74-9,77274-98-7) → (2S,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidin-2-one (54750-13-9) + (2R,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidin-2-one (54750-12-8)

Guidance literature:

With triethylamine; trichlorophosphate; In toluene;

DOI:10.1002/mrc.1260290812

Reference yield: 12.0%

(1S,2R)-(+)-ephedrine (321-98-2,7009-81-6,90-83-5,6912-63-6) → (2R,4R,5S)-2-Chloro-3,4-dimethyl-5-phenyl-[1,3,2]oxazaphospholidine 2-oxide (31060-10-3) + (2S,4R,5S)-2-Chloro-3,4-dimethyl-5-phenyl-[1,3,2]oxazaphospholidine 2-oxide (13897-77-3,28080-18-4,28080-19-5,31060-10-3,31060-12-5,53625-09-5,53625-11-9,54750-12-8,54750-13-9,72691-41-9,149116-52-9)

Guidance literature:

With trichlorophosphate; In benzene;

DOI:10.1021/jo00311a017

upstream raw materials:

ephedrine hydrochloride

ephedrine

(-)-ephedrine hydrochloride

(1S,2R)-(+)-ephedrine

Downstream raw materials:

(4S)-2-methoxy-3,4r-dimethyl-5c-phenyl-[1,3,2]oxazaphospholidine 2c-oxide

(4S)-3,4r-dimethyl-2-phenoxy-5c-phenyl-[1,3,2]oxazaphospholidine 2c-oxide

(2R,4R,5S)-3,4-Dimethyl-2-(4-methoxyphenoxy)-5-phenyl-1,3,2-oxazaphospholidine 2-oxide

(E)-2-((2S,4S,5S)-3,4-Dimethyl-2-oxo-5-phenyl-2λ⁵-[1,3,2]oxazaphospholidin-2-yloxy)-pent-3-enenitrile

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