1-(2-CHLOROPHENYL)-N-(1-METHYLPROPYL)-ISOQUINOLINE-3-CARBOXAMIDE

Base Information

Chemical Name:1-(2-CHLOROPHENYL)-N-(1-METHYLPROPYL)-ISOQUINOLINE-3-CARBOXAMIDE
CAS No.:157809-85-3
Molecular Formula:C₂₀H₁₉ClN₂O
Molecular Weight:338.837
Hs Code.:
Mol file:157809-85-3.mol

Synonyms:3-Isoquinolinecarboxamide,1-(2-chlorophenyl)-N-(1-methylpropyl)-, (R)-

Suppliers and Price of 1-(2-CHLOROPHENYL)-N-(1-METHYLPROPYL)-ISOQUINOLINE-3-CARBOXAMIDE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of 1-(2-CHLOROPHENYL)-N-(1-METHYLPROPYL)-ISOQUINOLINE-3-CARBOXAMIDE

Chemical Property:

Boiling Point:502.2±45.0 °C(Predicted)
PKA:12.92±0.46(Predicted)
PSA：41.99000
Density:1.192±0.06 g/cm3(Predicted)
LogP:5.47440

Purity/Quality:: 99.3% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-(2-CHLOROPHENYL)-N-(1-METHYLPROPYL)-ISOQUINOLINE-3-CARBOXAMIDE

There total 8 articles about 1-(2-CHLOROPHENYL)-N-(1-METHYLPROPYL)-ISOQUINOLINE-3-CARBOXAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 33966-50-6
SEC-BUTYLAMINE

: 89242-09-1
1-(2-chlorophenyl)-3-isoquinolinecarboxylic acid

: 124236-61-9,157809-86-4,157809-85-3
(+/-)-1-(2-chlorophenyl)-N-(1-methylpropyl)-3-isoquinolinecarboxamide

Guidance literature:: 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 50 ℃;

SEC-BUTYLAMINE; In dichloromethane; Further stages.;
DOI:10.1016/j.tetlet.2007.07.203

Reference yield:

: 89242-09-1
1-(2-chlorophenyl)-3-isoquinolinecarboxylic acid

: 124236-61-9,157809-86-4,157809-85-3
(+/-)-1-(2-chlorophenyl)-N-(1-methylpropyl)-3-isoquinolinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂; DMF / CH₂Cl₂ / 0.08 h

2: CH₂Cl₂

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1016/j.bmcl.2004.11.017