N-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3,5-difluorophenyl}-3-oxobutanamide

Base Information

Chemical Name:N-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3,5-difluorophenyl}-3-oxobutanamide
CAS No.:1288342-31-3
Molecular Formula:C₁₇H₁₄F₅N₃O₂
Molecular Weight:387.309
Hs Code.:

Synonyms:N-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3,5-difluorophenyl}-3-oxobutanamide

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Chemical Property of N-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3,5-difluorophenyl}-3-oxobutanamide

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Technology Process of N-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3,5-difluorophenyl}-3-oxobutanamide

There total 4 articles about N-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3,5-difluorophenyl}-3-oxobutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1694-31-1
tert-butyl acetoacetate

: 1288340-56-6
4-(5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)-3,5-difluoroaniline

: 1288342-31-3
N-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3,5-difluorophenyl}-3-oxobutanamide

Guidance literature:: In xylene; at 145 ℃; for 1.5h;

Reference yield:

: 30923-69-4
1‐cyclopropyl‐4,4,4‐trifluorobutane‐1,3‐dione

: 1288342-31-3
N-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3,5-difluorophenyl}-3-oxobutanamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / ethanol / Reflux

2: sodium hydride / tetrahydrofuran / 2 h / Reflux

3: ammonium chloride; iron / ethanol; water / 1 h / Reflux

4: xylene / 1.5 h / 145 °C

With iron; sodium hydride; ammonium chloride; hydrazine hydrate; In tetrahydrofuran; ethanol; water; xylene;

Reference yield:

: 1062295-85-5,1027617-86-2
3-cyclopropyl-5-(trifluoromethyl)-1H-pyrazole

: 1288342-31-3
N-{4-[5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-3,5-difluorophenyl}-3-oxobutanamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran / 2 h / Reflux

2: ammonium chloride; iron / ethanol; water / 1 h / Reflux

3: xylene / 1.5 h / 145 °C

With iron; sodium hydride; ammonium chloride; In tetrahydrofuran; ethanol; water; xylene;