1-{3-[3-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]phenyl}ethanone

Base Information

Chemical Name:1-{3-[3-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]phenyl}ethanone
CAS No.:1198211-15-2
Molecular Formula:C₂₁H₁₄Cl₂N₂O
Molecular Weight:381.261
Hs Code.:

Synonyms:1-{3-[3-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]phenyl}ethanone

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Chemical Property of 1-{3-[3-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]phenyl}ethanone

Chemical Property:

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Technology Process of 1-{3-[3-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]phenyl}ethanone

There total 4 articles about 1-{3-[3-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]phenyl}ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1198211-14-1
6-Bromo-3-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridine

: 3-acetylphenylboronic acid

: 1198211-15-2
1-{3-[3-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]phenyl}ethanone

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; toluene; acetonitrile; at 80 ℃; for 4h; Inert atmosphere;

Reference yield:

: 536-38-9
4-chlorobenzoylmethyl bromide

: 1198211-15-2
1-{3-[3-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]phenyl}ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / propan-1-ol / 18 h / 80 °C / Inert atmosphere

2: N-chloro-succinimide / methanol / 2 h / 20 °C / Inert atmosphere

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; acetonitrile; water / 4 h / 80 °C / Inert atmosphere

With N-chloro-succinimide; sodium hydrogencarbonate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; propan-1-ol; water; toluene; acetonitrile;

Reference yield:

: 1072-97-5
5-bromo-2-pyridylamine

: 1198211-15-2
1-{3-[3-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]phenyl}ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / propan-1-ol / 18 h / 80 °C / Inert atmosphere

2: N-chloro-succinimide / methanol / 2 h / 20 °C / Inert atmosphere

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; acetonitrile; water / 4 h / 80 °C / Inert atmosphere

With N-chloro-succinimide; sodium hydrogencarbonate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; propan-1-ol; water; toluene; acetonitrile;