2-{3-[3-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]phenyl}propan-2-ol

Base Information

Chemical Name:2-{3-[3-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]phenyl}propan-2-ol
CAS No.:1198211-13-0
Molecular Formula:C₂₂H₁₈Cl₂N₂O
Molecular Weight:397.304
Hs Code.:

Synonyms:2-{3-[3-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]phenyl}propan-2-ol

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Chemical Property of 2-{3-[3-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]phenyl}propan-2-ol

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Technology Process of 2-{3-[3-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]phenyl}propan-2-ol

There total 4 articles about 2-{3-[3-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]phenyl}propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1198211-15-2
1-{3-[3-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]phenyl}ethanone

: 75-16-1
methylmagnesium bromide

: 1198211-13-0
2-{3-[3-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]phenyl}propan-2-ol

Guidance literature:: 1-{3-[3-Chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]phenyl}ethanone; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 0 ℃; for 4h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether;

Reference yield:

: 1072-97-5
5-bromo-2-pyridylamine

: 1198211-13-0
2-{3-[3-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]phenyl}propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / propan-1-ol / 18 h / 80 °C / Inert atmosphere

2: N-chloro-succinimide / methanol / 2 h / 20 °C / Inert atmosphere

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; acetonitrile; water / 4 h / 80 °C / Inert atmosphere

4: diethyl ether; tetrahydrofuran / 4 h / 0 °C / Inert atmosphere

With N-chloro-succinimide; sodium hydrogencarbonate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; propan-1-ol; diethyl ether; water; toluene; acetonitrile;

Reference yield:

: 536-38-9
4-chlorobenzoylmethyl bromide

: 1198211-13-0
2-{3-[3-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]phenyl}propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / propan-1-ol / 18 h / 80 °C / Inert atmosphere

2: N-chloro-succinimide / methanol / 2 h / 20 °C / Inert atmosphere

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; acetonitrile; water / 4 h / 80 °C / Inert atmosphere

4: diethyl ether; tetrahydrofuran / 4 h / 0 °C / Inert atmosphere

With N-chloro-succinimide; sodium hydrogencarbonate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; propan-1-ol; diethyl ether; water; toluene; acetonitrile;