1,3,2',6',2''',6'''-hexaazido-6,3',4',2,3''',4'''-hexaacetoxy-4''-(prop-2-ynylcarbamoyl)neomycin B

Base Information

Chemical Name:1,3,2',6',2''',6'''-hexaazido-6,3',4',2,3''',4'''-hexaacetoxy-4''-(prop-2-ynylcarbamoyl)neomycin B
CAS No.:1144106-86-4
Molecular Formula:C₃₈H₄₇N₁₉O₁₉
Molecular Weight:1073.91
Hs Code.:

Synonyms:1,3,2',6',2''',6'''-hexaazido-6,3',4',2,3''',4'''-hexaacetoxy-4''-(prop-2-ynylcarbamoyl)neomycin B

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Chemical Property of 1,3,2',6',2''',6'''-hexaazido-6,3',4',2,3''',4'''-hexaacetoxy-4''-(prop-2-ynylcarbamoyl)neomycin B

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Technology Process of 1,3,2',6',2''',6'''-hexaazido-6,3',4',2,3''',4'''-hexaacetoxy-4''-(prop-2-ynylcarbamoyl)neomycin B

There total 2 articles about 1,3,2',6',2''',6'''-hexaazido-6,3',4',2,3''',4'''-hexaacetoxy-4''-(prop-2-ynylcarbamoyl)neomycin B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1144106-85-3
1,3,2',6',2''',6'''-hexaazido-6,3',4',2,3'',4'''-hexaacetoxyneomycin-B-4''-carboxylic acid

: 2450-71-7
Propargylamine

: 1144106-86-4
1,3,2',6',2''',6'''-hexaazido-6,3',4',2,3''',4'''-hexaacetoxy-4''-(prop-2-ynylcarbamoyl)neomycin B

Guidance literature:: 1,3,2',6',2''',6'''-hexaazido-6,3',4',2",3'',4'''-hexaacetoxyneomycin-B-4''-carboxylic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Propargylamine; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm900028n

Reference yield:

: 620172-08-9
acetic acid 2-[3-acetoxy-4-(4,5-diacetoxy-3-azido-6-azidomethyl-tetrahydro-pyran-2-yloxy)-5-hydroxymethyl-tetrahydro-furan-2-yloxy]-4,6-diazido-3-(4,5-diacetoxy-3-azido-6-azidomethyl-tetrahydro-pyran-2-yloxy)-cyclohexyl ester

: 1144106-86-4
1,3,2',6',2''',6'''-hexaazido-6,3',4',2,3''',4'''-hexaacetoxy-4''-(prop-2-ynylcarbamoyl)neomycin B

Guidance literature:: Multi-step reaction with 2 steps

1.1: [bis(acetoxy)iodo]benzene; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 0.07 h / 5 - 20 °C / Inert atmosphere

2.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 1 h / 0 °C / Inert atmosphere

2.2: 4 h / 20 °C / Inert atmosphere

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; water;