84541-36-6

Basic information

• Product Name: 6-METHOXY-2-(4-METHOXY PHENYL)-BENZO[B]THIEN-3-YL][4-[2-(1-[PIPERIDINYL)ETHOXY]PHENYL]METHANONE HYDROCHLORIDE
• Synonyms: 6-METHOXY-2-(4-METHOXY PHENYL)-BENZO[B]THIEN-3-YL][4-[2-(1-[PIPERIDINYL)ETHOXY]PHENYL]METHANONE HYDROCHLORIDE;6-HYDROXY-2-(4-HYDROXYPHENYL)-BENZOTHIOPHEN-3-YL]-[4-[2-(1-PIPERIDYL)ETHOXY]PHENYL]-METHANONE;[6-Methoxy-2-(4-methoxyphenyl)-1-benzothiophen-3-yl]{4-[2-(1-pipe ridinyl)ethoxy]phenyl}methanone HCl
• CAS NO: 84541-36-6
• Molecular Formula: C₃₀H₃₁NO₄S*ClH
• Molecular Weight: 538.1
• Mol File: 84541-36-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-METHOXY-2-(4-METHOXY PHENYL)-BENZO[B]THIEN-3-YL][4-[2-(1-[PIPERIDINYL)ETHOXY]PHENYL]METHANONE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-METHOXY-2-(4-METHOXY PHENYL)-BENZO[B]THIEN-3-YL][4-[2-(1-[PIPERIDINYL)ETHOXY]PHENYL]METHANONE HYDROCHLORIDE(84541-36-6)
• EPA Substance Registry System: 6-METHOXY-2-(4-METHOXY PHENYL)-BENZO[B]THIEN-3-YL][4-[2-(1-[PIPERIDINYL)ETHOXY]PHENYL]METHANONE HYDROCHLORIDE(84541-36-6)

Safety Data

• Hazardous Substances Data: 84541-36-6(Hazardous Substances Data)

Usage

General Description

6-Methoxy-2-(4-methoxy phenyl)benzo[b]thien-3-yl][4-[2-(1-[piperidinyl)ethoxy]phenyl]methanone hydrochloride is a chemical compound with potential pharmacological properties. It contains a benzothiophene structure with an additional phenyl and methoxy group, as well as a ketone and piperidine moiety. 6-METHOXY-2-(4-METHOXY PHENYL)-BENZO[B]THIEN-3-YL][4-[2-(1-[PIPERIDINYL)ETHOXY]PHENYL]METHANONE HYDROCHLORIDE may exhibit a range of biological activities, including potential antipsychotic, antidepressant, or anxiolytic effects, due to its interaction with neurotransmitter systems in the brain. Additionally, the hydrochloride salt form enhances its solubility and stability, making it suitable for pharmaceutical applications. Research into the potential therapeutic uses and pharmacological properties of 6-Methoxy-2-(4-methoxy phenyl)benzo[b]thien-3-yl][4-[2-(1-[piperidinyl)ethoxy]phenyl]methanone hydrochloride is ongoing, with the aim of developing new treatments for various mental health disorders.

Upstream product

• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
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• 120-47-8 Ethyl 4-hydroxybenzoate 
• 1293362-54-5 1-(2-{4-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy}-ethyl)-piperidinium bromide 
• 84541-38-8 [6-Methoxy-2-(4-Methoxyphenyl)benzo[b]thien-3-yl]-[4-[2-(1-Piperidinyl)ethoxy]phenyl] Methanone 
• 63676-19-7 [6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl](4-hydroxyphenyl)methanone 
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• 63675-74-1 2-(4'-methoxyphenyl)-6-methoxybenzothiophene 
• 166975-76-4 4-(2-(piperidin-1-yl)ethoxy)benzoyl chloride 
• 84449-80-9 4-(2-piperidin-1-ylethoxy)benzoic acid hydrochloride 

Downstream Products

• 84541-38-8 [6-Methoxy-2-(4-Methoxyphenyl)benzo[b]thien-3-yl]-[4-[2-(1-Piperidinyl)ethoxy]phenyl] Methanone 
• 1293362-54-5 1-(2-{4-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy}-ethyl)-piperidinium bromide 
• 82640-04-8 raloxifene hydrochloride 

Relevant articles and documents

A PROCESS FOR PREPARING BENZO[B]THIOPHENE DERIVATIVES

The present invention relates in general to the field of organic chemistry, and in particular to the preparation of benzo[b]thiophene derivatives. These benzo[b]thiophene derivatives are useful as intermediates in the synthesis of pharmaceutically active agents such as raloxifene or derivatives thereof.

A PROCESS FOR PREPARING BENZO[B]THIOPHENE DERIVATIVES

The present invention relates in general to the field of organic chemistry, and in particular to the preparation of benzo[b]thiophene derivatives. These benzo[b]thiophene derivatives are useful as intermediates in the synthesis of pharmaceutically active agents such as raloxifene or derivatives thereof.

Antiestrogens. 2. Structure-Activity Studies in a Series of 3-Aroyl-2-arylbenzothiophene Derivatives Leading to thien-3-yl>phenyl>methanone Hydrochloride (LY156758), a Remarkably Effective Estrogen Antagonist with On...

In an effort to prepare nonsteroidal antiestrogens demonstrating greater antagonism and less intrinsic estrogenicity than those currently available, a series of 3-aroyl-2-arylbenzothiophene derivatives was synthesized.These compounds were prepared by Friedel-Crafts aroylation of appropriate O-protected 2-arylbenzothiophene nuclei with basic side-chain-bearing benzoyl chlorides followed by removal of the protective groups to provide the desired compounds containing both hydroxyl and basic side-chain functionality.A particularly useful method for the cleavage of aryl methoxy ethers without removal of (dialkylamino)ethoxy side chain functionality elsewhere in the molecule was found to be AlCl3/EtSH.The benzothiophene derivatives were tested for their ability to inhibit the growth-stimulating action of estradiol on the immature rat uterus.Seemingly minor changes in the side-chain amine moiety were found to have profound effects on the ability of the compounds to antagonize estradiol.Analogues having basic side chains containing cyclic (pyrrolidine, piperidine, and hexamethyleneamine) moieties were found to have less intrinsic estrogenicity and to antagonize estradiol action more completely than their noncyclic counterparts.The most effective antiestrogen in the series, compound 44, thien-3-yl>phenyl>methanone, elicited a modest uterotropic activity that did not increase with increasing dose.In antagonism of estradiol, 44 exhibited a degree of inhibition surpassing that of tamoxifen at any dose tested.The new benzothiophene antiestrogen was also shown to have high affinity for rat uterine cycloplasmic estrogen receptor and to be an inhibitor of the growth of DMBA-induced rat mammary tumors.