84541-36-6

Usage

Uses

Used in Pharmaceutical Industry:
6-Methoxy-2-(4-methoxy phenyl)benzo[b]thien-3-yl][4-[2-(1-[piperidinyl)ethoxy]phenyl]methanone hydrochloride is used as a potential therapeutic agent for mental health disorders due to its potential antipsychotic, antidepressant, or anxiolytic effects. Its interaction with neurotransmitter systems in the brain makes it a candidate for the development of new treatments for various mental health conditions.
Research is ongoing to explore the full range of pharmacological properties and potential therapeutic uses of 6-METHOXY-2-(4-METHOXY PHENYL)-BENZO[B]THIEN-3-YL][4-[2-(1-[PIPERIDINYL)ETHOXY]PHENYL]METHANONE HYDROCHLORIDE, with the aim of advancing the understanding of its mechanisms of action and optimizing its efficacy and safety profile for clinical applications.

Upstream product

• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 7507-41-7 4-benzenesulfonyloxy-benzoic acid 
• 1293362-49-8 benzenesulfonic acid-4-[6-methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenyl ester 
• 1286990-00-8 ethyl 4-((phenylsulfonyl)oxy)benzoate 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 1293362-54-5 1-(2-{4-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy}-ethyl)-piperidinium bromide 
• 84541-38-8 [6-Methoxy-2-(4-Methoxyphenyl)benzo[b]thien-3-yl]-[4-[2-(1-Piperidinyl)ethoxy]phenyl] Methanone 
• 63676-19-7 [6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl](4-hydroxyphenyl)methanone 
• 2008-75-5 N-chloroethylpiperidine hydrochloride 
• 84449-80-9 4-(2-piperidin-1-ylethoxy)benzoic acid hydrochloride 
• 63675-73-0 α-(3-methoxyphenyl-thio)-4-methoxyacetophenone 
• 15570-12-4 3-methoxybenzenethiol 
• 63675-74-1 2-(4'-methoxyphenyl)-6-methoxybenzothiophene 
• 166975-76-4 4-(2-(piperidin-1-yl)ethoxy)benzoyl chloride 

Downstream Products

• 84541-38-8 [6-Methoxy-2-(4-Methoxyphenyl)benzo[b]thien-3-yl]-[4-[2-(1-Piperidinyl)ethoxy]phenyl] Methanone 
• 1293362-54-5 1-(2-{4-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy}-ethyl)-piperidinium bromide 
• 82640-04-8 raloxifene hydrochloride 

Relevant academic research and scientific papers

A PROCESS FOR PREPARING BENZO[B]THIOPHENE DERIVATIVES

The present invention relates in general to the field of organic chemistry, and in particular to the preparation of benzo[b]thiophene derivatives. These benzo[b]thiophene derivatives are useful as intermediates in the synthesis of pharmaceutically active agents such as raloxifene or derivatives thereof.

A process for preparing benzo[b]thiophene derivatives

The present invention relates in general to the field of organic chemistry, and in particular to the preparation of benzo[b]thiophene derivatives. These benzo[b]thiophene derivatives are useful as intermediates in the synthesis of pharmaceutically active agents such as raloxifene or derivatives thereof.

A PROCESS FOR PREPARING BENZO[B]THIOPHENE DERIVATIVES

The present invention relates in general to the field of organic chemistry, and in particular to the preparation of benzo[b]thiophene derivatives. These benzo[b]thiophene derivatives are useful as intermediates in the synthesis of pharmaceutically active agents such as raloxifene or derivatives thereof.

A process for preparing benzo[b]thiophene derivatives

The present invention relates in general to the field of organic chemistry, and in particular to the preparation of benzo[b]thiophene derivatives. These benzo[b]thiophene derivatives are useful as intermediates in the synthesis of pharmaceutically active agents such as raloxifene or derivatives thereof.

Antiestrogens. 2. Structure-Activity Studies in a Series of 3-Aroyl-2-arylbenzothiophene Derivatives Leading to thien-3-yl>phenyl>methanone Hydrochloride (LY156758), a Remarkably Effective Estrogen Antagonist with On...

In an effort to prepare nonsteroidal antiestrogens demonstrating greater antagonism and less intrinsic estrogenicity than those currently available, a series of 3-aroyl-2-arylbenzothiophene derivatives was synthesized.These compounds were prepared by Friedel-Crafts aroylation of appropriate O-protected 2-arylbenzothiophene nuclei with basic side-chain-bearing benzoyl chlorides followed by removal of the protective groups to provide the desired compounds containing both hydroxyl and basic side-chain functionality.A particularly useful method for the cleavage of aryl methoxy ethers without removal of (dialkylamino)ethoxy side chain functionality elsewhere in the molecule was found to be AlCl3/EtSH.The benzothiophene derivatives were tested for their ability to inhibit the growth-stimulating action of estradiol on the immature rat uterus.Seemingly minor changes in the side-chain amine moiety were found to have profound effects on the ability of the compounds to antagonize estradiol.Analogues having basic side chains containing cyclic (pyrrolidine, piperidine, and hexamethyleneamine) moieties were found to have less intrinsic estrogenicity and to antagonize estradiol action more completely than their noncyclic counterparts.The most effective antiestrogen in the series, compound 44, thien-3-yl>phenyl>methanone, elicited a modest uterotropic activity that did not increase with increasing dose.In antagonism of estradiol, 44 exhibited a degree of inhibition surpassing that of tamoxifen at any dose tested.The new benzothiophene antiestrogen was also shown to have high affinity for rat uterine cycloplasmic estrogen receptor and to be an inhibitor of the growth of DMBA-induced rat mammary tumors.