tert-butyl (3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylcarbamate

Base Information

Chemical Name:tert-butyl (3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylcarbamate
CAS No.:1374443-91-0
Molecular Formula:C₂₆H₂₃F₃N₄O₆
Molecular Weight:544.487
Hs Code.:

Synonyms:tert-butyl (3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylcarbamate

Chemical Property:

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Technology Process of tert-butyl (3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylcarbamate

There total 12 articles about tert-butyl (3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1374443-91-0
tert-butyl (3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylcarbamate

Guidance literature:: Multi-step reaction with 8 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2: triethylamine / 1,2-dichloro-ethane / 2.5 h / 70 °C

3: Jones reagent / acetone / 20 °C

4: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 20 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile

6: methanol; tin(II) chloride dihdyrate / dichloromethane / 10 h

7: triethylamine / water; tetrahydrofuran / 2 h

8: Lux-Cellulose-2 / ethanol / 35 °C / Resolution of racemate

With pyridine; methanol; N-chloro-succinimide; Jones reagent; trifluoro-[1,3,5]triazine; tin(II) chloride dihdyrate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: rac-(3R*,4S*) tert-butyl-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylcarbamate

: 1374443-91-0
tert-butyl (3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylcarbamate

: 1374443-90-9
tert-butyl (3S,4R)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylcarbamate

Guidance literature:: With Lux-Cellulose-2; In ethanol; at 35 ℃; Resolution of racemate;

Reference yield:

: 1236188-79-6
(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)methanol

: 1374443-91-0
tert-butyl (3R,4S)-4-hydroxy-7-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)chroman-3-ylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: Jones reagent / acetone / 20 °C

2: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 20 °C

3: N-ethyl-N,N-diisopropylamine / acetonitrile

4: methanol; tin(II) chloride dihdyrate / dichloromethane / 10 h

5: triethylamine / water; tetrahydrofuran / 2 h

6: Lux-Cellulose-2 / ethanol / 35 °C / Resolution of racemate

With pyridine; methanol; Jones reagent; trifluoro-[1,3,5]triazine; tin(II) chloride dihdyrate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water; acetone; acetonitrile;