2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetamide

Base Information

Chemical Name:2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetamide
CAS No.:157599-02-5
Molecular Formula:C₁₆H₃₂N₈O₄
Molecular Weight:400.481
Hs Code.:2933990090
European Community (EC) Number:681-456-3
DSSTox Substance ID:DTXSID90468610
Nikkaji Number:J674.239D
Wikipedia:DOTAM
Mol file:157599-02-5.mol

Synonyms:1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane;DOTAM cpd

Suppliers and Price of 2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
DOTAM
250mg
$ 140.00

Matrix Scientific
2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetamide 95+%
1g
$ 672.00

Matrix Scientific
2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetamide 95+%
250mg
$ 303.00

Crysdot
2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetamide 97%
1g
$ 282.00

Crysdot
2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetamide 97%
10g
$ 1471.00

Crysdot
2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetamide 97%
5g
$ 876.00

Chemenu
2,2'',2'''',2''''''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetamide 97%
1g
$ 267.00

Chemenu
2,2'',2'''',2''''''-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetamide 97%
5g
$ 828.00

Ark Pharm
2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetamide 97%
100mg
$ 11.00

American Custom Chemicals Corporation
1,4,7,10-TETRAKIS(AMINOCARBONYLMETHYL)-1,4,7,10-TETRAAZACYCLODODECANE 95.00%
5MG
$ 503.29

Total 37 raw suppliers

Chemical Property of 2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetamide

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.534
Boiling Point:767.394 °C at 760 mmHg
PKA:15.76±0.40(Predicted)
Flash Point:417.905 °C
PSA：185.32000
Density:1.211 g/cm³
LogP:-2.29800
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Sensitive.:Hygroscopic
Solubility.:Water (Slightly, Heated, Sonicated)
XLogP3:-4.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:8
Exact Mass:400.25465153
Heavy Atom Count:28
Complexity:447

Purity/Quality:

97% ^*data from raw suppliers

DOTAM ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN(CCN(CCN1CC(=O)N)CC(=O)N)CC(=O)N)CC(=O)N
General Description 1,4,7,10-Tetrakis(aminocarbonylmethyl)-1,4,7,10-tetraazacyclododecane (also known as DOTAM) is an octadentate macrocyclic ligand that forms stable complexes with various metal ions, including Zn(II), Cd(II), Ca(II), and lanthanides. Its coordination involves four nitrogen atoms from the cyclen ring and four oxygen atoms from the pendant amide groups, leading to distorted geometries with distinct metal-oxygen bond lengths. The ligand exhibits high selectivity for heavy metal ions like Cd(II) and Pb(II), with exceptionally high stability constants (logK1 > 19). Additionally, its complexes display dynamic structural fluctuations in solution, such as helicity interchange and diastereomeric equilibria, which influence their physicochemical properties. The amide oxygen donors contribute to enhanced complex stability, particularly for larger metal ions, while molecular mechanics studies suggest van der Waals interactions play a role in coordination geometry. DOTAM-derived frameworks also show potential for multinuclear complexation with improved kinetic stability and functional applications, such as in MRI contrast agents.

Technology Process of 2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetamide

There total 2 articles about 2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%