3-benzyloxy-2-(4-chloro-benzyl)-7,8,9,10-tetrahydro-benzo[h]quinoline-4-carboxylic acid benzyl ester

Base Information

Chemical Name:3-benzyloxy-2-(4-chloro-benzyl)-7,8,9,10-tetrahydro-benzo[h]quinoline-4-carboxylic acid benzyl ester
CAS No.:924633-96-5
Molecular Formula:C₃₅H₃₀ClNO₃
Molecular Weight:548.081
Hs Code.:

3-benzyloxy-2-(4-chloro-benzyl)-7,8,9,10-tetrahydro-benzo[<i>h</i>]quinoline-4-carboxylic acid benzyl ester

Synonyms:3-benzyloxy-2-(4-chloro-benzyl)-7,8,9,10-tetrahydro-benzo[h]quinoline-4-carboxylic acid benzyl ester

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Chemical Property of 3-benzyloxy-2-(4-chloro-benzyl)-7,8,9,10-tetrahydro-benzo[h]quinoline-4-carboxylic acid benzyl ester

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Technology Process of 3-benzyloxy-2-(4-chloro-benzyl)-7,8,9,10-tetrahydro-benzo[h]quinoline-4-carboxylic acid benzyl ester

There total 5 articles about 3-benzyloxy-2-(4-chloro-benzyl)-7,8,9,10-tetrahydro-benzo[h]quinoline-4-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 851546-61-7
2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid

: 100-39-0
benzyl bromide

: 924633-96-5
3-benzyloxy-2-(4-chloro-benzyl)-7,8,9,10-tetrahydro-benzo[h]quinoline-4-carboxylic acid benzyl ester

Guidance literature:: With potassium carbonate; In acetone; at 25 ℃; for 16h;
DOI:10.1021/jm060631p

Reference yield:

: 1878-66-6
4-chlorophenylacetic Acid

: 924633-96-5
3-benzyloxy-2-(4-chloro-benzyl)-7,8,9,10-tetrahydro-benzo[h]quinoline-4-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl chloride; DMF / tetrahydrofuran / 1 h

2.1: diethyl ether; tetrahydrofuran

2.2: 74 percent / HCl / diethyl ether; tetrahydrofuran

3.1: 55 percent / AcOH / ethanol / 3 h / Heating

4.1: 41 percent / aq. KOH / ethanol / 5 h / Heating

5.1: 70 percent / K₂CO₃ / acetone / 16 h / 25 °C

With potassium hydroxide; oxalyl dichloride; potassium carbonate; acetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether; ethanol; acetone; 4.1: Pfitzinger reaction;
DOI:10.1021/jm060631p

Reference yield:

: 33107-83-4
1-chloro-3-(4-chlorophenyl)propan-2-one

: 924633-96-5
3-benzyloxy-2-(4-chloro-benzyl)-7,8,9,10-tetrahydro-benzo[h]quinoline-4-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / AcOH / ethanol / 3 h / Heating

2: 41 percent / aq. KOH / ethanol / 5 h / Heating

3: 70 percent / K₂CO₃ / acetone / 16 h / 25 °C

With potassium hydroxide; potassium carbonate; acetic acid; In ethanol; acetone; 2: Pfitzinger reaction;
DOI:10.1021/jm060631p