(S,Z)-N-(3,3-bis(4-methoxyphenyl)isobenzofuran-1(3H)-ylidene)-3-methyl-1-(pyridin-2-yloxy)butan-2-amine

Base Information

• Chemical Name: (S,Z)-N-(3,3-bis(4-methoxyphenyl)isobenzofuran-1(3H)-ylidene)-3-methyl-1-(pyridin-2-yloxy)butan-2-amine
• CAS No.: 1609493-13-1
• Molecular Formula: C₃₂H₃₂N₂O₄
• Molecular Weight: 508.617
• Mol file: 1609493-13-1.mol

Synonyms:(S,Z)-N-(3,3-bis(4-methoxyphenyl)isobenzofuran-1(3H)-ylidene)-3-methyl-1-(pyridin-2-yloxy)butan-2-amine

Chemical Property of (S,Z)-N-(3,3-bis(4-methoxyphenyl)isobenzofuran-1(3H)-ylidene)-3-methyl-1-(pyridin-2-yloxy)butan-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S,Z)-N-(3,3-bis(4-methoxyphenyl)isobenzofuran-1(3H)-ylidene)-3-methyl-1-(pyridin-2-yloxy)butan-2-amine

There total 2 articles about (S,Z)-N-(3,3-bis(4-methoxyphenyl)isobenzofuran-1(3H)-ylidene)-3-methyl-1-(pyridin-2-yloxy)butan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-fluoropyridine (372-48-5) + (S,Z)-2-((3,3-bis(4-methoxyphenyl)isobenzofuran-1(3H)-ylidene)amino)-3-methylbutan-1-ol (1609493-09-5) → (S,Z)-N-(3,3-bis(4-methoxyphenyl)isobenzofuran-1(3H)-ylidene)-3-methyl-1-(pyridin-2-yloxy)butan-2-amine (1609493-13-1)

Guidance literature:

(S,Z)-2-((3,3-bis(4-methoxyphenyl)isobenzofuran-1(3H)-ylidene)amino)-3-methylbutan-1-ol; With sodium hydride; In tetrahydrofuran; mineral oil; for 0.0833333h;

2-fluoropyridine; In tetrahydrofuran; mineral oil; at 20 ℃;

DOI:10.1039/c4cc01060d

Reference yield:

bis(p-methoxyphenyl)methanone (90-96-0) + (-)-(S)-2-(2-bromo-phenyl)-4-isopropyl-4,5-dihydro-oxazole (148836-24-2) → (S,Z)-N-(3,3-bis(4-methoxyphenyl)isobenzofuran-1(3H)-ylidene)-3-methyl-1-(pyridin-2-yloxy)butan-2-amine (1609493-13-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.83 h / -89 °C

1.2: 16 h / -89 - 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h

2.2: 20 °C

With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; mineral oil;

DOI:10.1039/c4cc01060d

Reference yield: 97.0%

dichloro bis(acetonitrile) palladium(II) (21264-30-2,90243-59-7,14592-56-4) + (S,Z)-N-(3,3-bis(4-methoxyphenyl)isobenzofuran-1(3H)-ylidene)-3-methyl-1-(pyridin-2-yloxy)butan-2-amine (1609493-13-1) → C32H32Cl2N2O4Pd*1.2CH2Cl2

Guidance literature:

In dichloromethane; at 20 ℃; for 1h;

DOI:10.1039/c4cc01060d

upstream raw materials:

2-fluoropyridine

(S,Z)-2-((3,3-bis(4-methoxyphenyl)isobenzofuran-1(3H)-ylidene)amino)-3-methylbutan-1-ol

bis(p-methoxyphenyl)methanone

(-)-(S)-2-(2-bromo-phenyl)-4-isopropyl-4,5-dihydro-oxazole