Benzo[b]thiophene-4-carboxylic acid, 7-amino-, methyl ester (9CI)

Base Information

• Chemical Name: Benzo[b]thiophene-4-carboxylic acid, 7-amino-, methyl ester (9CI)
• CAS No.: 157252-28-3
• Molecular Formula: C₁₀H₉NO₂S
• Molecular Weight: 207.253
• Mol file: 157252-28-3.mol

Synonyms:Benzo[b]thiophene-4-carboxylic acid, 7-amino-, methyl ester (9CI)

Chemical Property of Benzo[b]thiophene-4-carboxylic acid, 7-amino-, methyl ester (9CI)

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzo[b]thiophene-4-carboxylic acid, 7-amino-, methyl ester (9CI)

There total 2 articles about Benzo[b]thiophene-4-carboxylic acid, 7-amino-, methyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

2-methoxyfuran (25414-22-6) + thiophene-2-carbothioamide (20300-02-1) → 7-Amino-benzo[b]thiophene-4-carboxylic acid methyl ester (157252-28-3) + 2-Methoxy-5-thiophen-2-yl-1H-pyrrole-3-carbaldehyde

Guidance literature:

In benzene; for 20h; Irradiation;

DOI:10.1039/c39940001477

Reference yield:

methanol (67-56-1) + thiophene-2-carbothioamide (20300-02-1) + (furan-2-yloxy)-trimethylsilane (61550-02-5) → 7-Amino-benzo[b]thiophene-4-carboxylic acid methyl ester (157252-28-3)

Guidance literature:

With hydrogenchloride; Yield given. Multistep reaction; 1.) benzene, RT, irrad., 5 h, 2.) reflux, 2 h;

DOI:10.1248/cpb.45.584

upstream raw materials:

2-methoxyfuran

thiophene-2-carbothioamide

methanol

(furan-2-yloxy)-trimethylsilane