(Z)-3,3,3-trifluoro-2-iodo-1-[4-(2-chloroethoxy)phenyl]-1-phenylpropene

Base Information

Chemical Name:(Z)-3,3,3-trifluoro-2-iodo-1-[4-(2-chloroethoxy)phenyl]-1-phenylpropene
CAS No.:867182-60-3
Molecular Formula:C₁₇H₁₃ClF₃IO
Molecular Weight:452.642
Hs Code.:

Synonyms:(Z)-3,3,3-trifluoro-2-iodo-1-[4-(2-chloroethoxy)phenyl]-1-phenylpropene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-3,3,3-trifluoro-2-iodo-1-[4-(2-chloroethoxy)phenyl]-1-phenylpropene

Chemical Property:

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Technology Process of (Z)-3,3,3-trifluoro-2-iodo-1-[4-(2-chloroethoxy)phenyl]-1-phenylpropene

There total 4 articles about (Z)-3,3,3-trifluoro-2-iodo-1-[4-(2-chloroethoxy)phenyl]-1-phenylpropene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80-41-1
2-chloroethyl tosylate

: 4-((Z)-3,3,3-Trifluoro-2-iodo-1-phenyl-propenyl)-phenol

: 867182-60-3
(Z)-3,3,3-trifluoro-2-iodo-1-[4-(2-chloroethoxy)phenyl]-1-phenylpropene

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 - 80 ℃; for 2h;
DOI:10.1021/ol036440n

Reference yield:

: 772-62-3
3,3,3-trifluoro-1-phenylpropyne

: 867182-60-3
(Z)-3,3,3-trifluoro-2-iodo-1-[4-(2-chloroethoxy)phenyl]-1-phenylpropene

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(I) cyanide / tetrahydrofuran / -45 - -5 °C

1.2: 51 percent / iodine / tetrahydrofuran / 1 h

2.1: boron tribromide / CH₂Cl₂ / 1 h / 20 °C

3.1: 74 mg / NaH / dimethylformamide / 0 - 80 °C

With copper(l) cyanide; boron tribromide; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2005.07.022

Reference yield:

: 13139-86-1
4-methoxyphenyl magnesium bromide

: 867182-60-3
(Z)-3,3,3-trifluoro-2-iodo-1-[4-(2-chloroethoxy)phenyl]-1-phenylpropene

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(I) cyanide / tetrahydrofuran / -45 - -5 °C

1.2: 51 percent / iodine / tetrahydrofuran / 1 h

2.1: boron tribromide / CH₂Cl₂ / 1 h / 20 °C

3.1: 74 mg / NaH / dimethylformamide / 0 - 80 °C

With copper(l) cyanide; boron tribromide; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2005.07.022