1-benzenesulfonyl-2-[(triphenyl-λ⁵-phosphanylidene)-acetyl]-1H-indole-3-carboxylic acid methyl ester

Base Information

• Chemical Name: 1-benzenesulfonyl-2-[(triphenyl-λ⁵-phosphanylidene)-acetyl]-1H-indole-3-carboxylic acid methyl ester
• CAS No.: 364079-01-6
• Molecular Formula: C₃₆H₂₈NO₅PS
• Molecular Weight: 617.662

Synonyms:1-benzenesulfonyl-2-[(triphenyl-λ⁵-phosphanylidene)-acetyl]-1H-indole-3-carboxylic acid methyl ester

Chemical Property of 1-benzenesulfonyl-2-[(triphenyl-λ⁵-phosphanylidene)-acetyl]-1H-indole-3-carboxylic acid methyl ester

Chemical Property:

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Technology Process of 1-benzenesulfonyl-2-[(triphenyl-λ⁵-phosphanylidene)-acetyl]-1H-indole-3-carboxylic acid methyl ester

There total 4 articles about 1-benzenesulfonyl-2-[(triphenyl-λ⁵-phosphanylidene)-acetyl]-1H-indole-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methanol (67-56-1) + [2-(1-benzenesulfonyl-3-carboxyindol-2-yl)-2-oxoethylidene]triphenylphosphorane (364078-85-3) → 1-benzenesulfonyl-2-[(triphenyl-λ5-phosphanylidene)-acetyl]-1H-indole-3-carboxylic acid methyl ester (364079-01-6)

Guidance literature:

With sulfuric acid; for 11h; Heating;

DOI:10.3987/COM-01-9230

Reference yield:

Methylenetriphenylphosphorane (19493-09-5) → 1-benzenesulfonyl-2-[(triphenyl-λ5-phosphanylidene)-acetyl]-1H-indole-3-carboxylic acid methyl ester (364079-01-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / tetrahydrofuran / 3 h / 0 °C

2: 80 percent / conc. sulfuric acid / 11 h / Heating

With sulfuric acid; In tetrahydrofuran;

DOI:10.3987/COM-01-9230

Reference yield:

1-(benzenesulfonyl)indole-2,3-dicarboxylic anhydride (192991-42-7) → 1-benzenesulfonyl-2-[(triphenyl-λ5-phosphanylidene)-acetyl]-1H-indole-3-carboxylic acid methyl ester (364079-01-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / tetrahydrofuran / 3 h / 0 °C

2: 80 percent / conc. sulfuric acid / 11 h / Heating

With sulfuric acid; In tetrahydrofuran;

DOI:10.3987/COM-01-9230

upstream raw materials:

methanol

[2-(1-benzenesulfonyl-3-carboxyindol-2-yl)-2-oxoethylidene]triphenylphosphorane

Methylenetriphenylphosphorane

1-(benzenesulfonyl)indole-2,3-dicarboxylic anhydride

Downstream raw materials:

[2-(3-methoxycarbonylindol-2-yl)-2-oxoethylidene]triphenylphosphorane

(E)-1-(3-methoxycarbonylindol-2-yl)-3-phenyl-2-propen-1-one

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