1,1-dimethylethyl (R)-2,5-diaza-5-(bromoacetyl)-9,9,10,10-tetramethyl-8-oxa-6-phenyl-9-silaundecanoate

Base Information

Chemical Name:1,1-dimethylethyl (R)-2,5-diaza-5-(bromoacetyl)-9,9,10,10-tetramethyl-8-oxa-6-phenyl-9-silaundecanoate
CAS No.:156022-74-1
Molecular Formula:C₂₃H₃₉BrN₂O₄Si
Molecular Weight:515.563
Hs Code.:

Synonyms:1,1-dimethylethyl (R)-2,5-diaza-5-(bromoacetyl)-9,9,10,10-tetramethyl-8-oxa-6-phenyl-9-silaundecanoate

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Chemical Property of 1,1-dimethylethyl (R)-2,5-diaza-5-(bromoacetyl)-9,9,10,10-tetramethyl-8-oxa-6-phenyl-9-silaundecanoate

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Technology Process of 1,1-dimethylethyl (R)-2,5-diaza-5-(bromoacetyl)-9,9,10,10-tetramethyl-8-oxa-6-phenyl-9-silaundecanoate

There total 5 articles about 1,1-dimethylethyl (R)-2,5-diaza-5-(bromoacetyl)-9,9,10,10-tetramethyl-8-oxa-6-phenyl-9-silaundecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 79-08-3
bromoacetic acid

: 156022-73-0
1,1-dimethylethyl (R)-2,5-diaza-9,9,10,10-tetramethyl-8-oxa-6-phenyl-9-silaundecanoate

: 156022-74-1
1,1-dimethylethyl (R)-2,5-diaza-5-(bromoacetyl)-9,9,10,10-tetramethyl-8-oxa-6-phenyl-9-silaundecanoate

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; Ambient temperature;
DOI:10.1016/S0040-4039(00)77163-2

Reference yield:

: 4530-20-5
BOC-glycine

: 156022-74-1
1,1-dimethylethyl (R)-2,5-diaza-5-(bromoacetyl)-9,9,10,10-tetramethyl-8-oxa-6-phenyl-9-silaundecanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / DCC / CH₂Cl₂ / 7 h / 0 - 20 °C

2: 94 percent / LiAlH₄ / diethyl ether / 24 h / Ambient temperature

3: 80 percent / imidazole / dimethylformamide / 18 h / Ambient temperature

4: 1.) DCC / 1.) CH₂Cl₂, RT, 30 min, 2.) CH₂Cl₂, RT, 24 h

With 1H-imidazole; lithium aluminium tetrahydride; dicyclohexyl-carbodiimide; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-1996-4299

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 156022-74-1
1,1-dimethylethyl (R)-2,5-diaza-5-(bromoacetyl)-9,9,10,10-tetramethyl-8-oxa-6-phenyl-9-silaundecanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / DCC / CH₂Cl₂ / 7 h / 0 - 20 °C

2: 94 percent / LiAlH₄ / diethyl ether / 24 h / Ambient temperature

3: 80 percent / imidazole / dimethylformamide / 18 h / Ambient temperature

4: 1.) DCC / 1.) CH₂Cl₂, RT, 30 min, 2.) CH₂Cl₂, RT, 24 h

With 1H-imidazole; lithium aluminium tetrahydride; dicyclohexyl-carbodiimide; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-1996-4299