EXO1

Base Information

• Chemical Name: EXO1
• CAS No.: 75541-83-2
• Molecular Formula: C₁₅H₁₂FNO₃
• Molecular Weight: 273.264
• Mol file: 75541-83-2.mol

Synonyms:EOX 1;EXOCYTIC INHIBITOR 1;EXO1;4-FLUORO-BZ-2-ABZ-OME;2-(4-FLUOROBENZOYLAMINO)BENZOIC ACID METHYL ESTER;2-(4-FLUOROBENZOYLAMINO)METHYLBENZOATE;2-(4-Fluoro-benzoylami;2-(4-Fluorobenzoylamino)benzoic acid methyl ester, 2-(4-Fluorobenzoylamino)methylbenzoate

Chemical Property of EXO1

Chemical Property:

• Vapor Pressure: 0.000132mmHg at 25°C
• Boiling Point: 333.9ºC at 760 mmHg
• Flash Point: 155.8 ºC
• PSA: 55.40000
• Density: 1.298 g/cm3
• LogP: 2.93760
• Storage Temp.: +2C to +8C
• Solubility.: DMSO: 19 mg/mL, soluble

Purity/Quality:

99% ^*data from raw suppliers

Exo 1 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Exo1 is a cell-permeable, reversible inhibitor of exocytosis (IC50 = 20 μM). It interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum by dissociating the GTPase activator ADP-ribosylation factor (ARF1) from Golgi membranes, which leads to a consequent collapse of the Golgi apparatus. Exo 1 acts as a cell-permeable reverse inhibitor of exocytosis. Potential anti-inflammatory activity. Exo 1 has been used as a component of the BRB80 buffer to study coat protein 1 (COPI)-mediated membrane trafficking. It has also been used as a Golgi inhibitor to study its effects on the long?interspersed?nuclear?element-1 (L1) retrotransposition.

Technology Process of EXO1

There total 1 articles about EXO1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-fluorobenzoyl chloride (403-43-0) + 2-carbomethoxyaniline (134-20-3) → methyl 2‐(4‐fluorobenzamido)benzoate (75541-83-2)

Guidance literature:

With pyridine; In chloroform; at 20 ℃;

DOI:10.1016/j.bmc.2021.116521

Reference yield:

methyl 2‐(4‐fluorobenzamido)benzoate (75541-83-2) → [nickel(II)(N′‐(3,5‐di‐tert‐butylsalicylidene)‐2‐(4‐fluorobenzamido)benzohydrazide)(dimethylformamide)]

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / methanol / 4 h / Reflux

2: acetic acid / methanol / 2 h / Reflux

3: sodium acetate / methanol / 6 h / Reflux

With sodium acetate; hydrazine hydrate; acetic acid; In methanol;

DOI:10.1002/aoc.4337

upstream raw materials:

4-fluorobenzoyl chloride

2-carbomethoxyaniline