1-Piperidinecarboxylic acid, 3-methoxy-4-oxo-, ethyl ester, (-)-

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 3-methoxy-4-oxo-, ethyl ester, (-)-
CAS No.:156970-96-6
Molecular Formula:C₉H₁₅NO₄
Molecular Weight:201.222
Hs Code.:
Mol file:156970-96-6.mol

Synonyms:1-Piperidinecarboxylic acid, 3-methoxy-4-oxo-, ethyl ester, (-)-

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Chemical Property of 1-Piperidinecarboxylic acid, 3-methoxy-4-oxo-, ethyl ester, (-)-

Chemical Property:

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Technology Process of 1-Piperidinecarboxylic acid, 3-methoxy-4-oxo-, ethyl ester, (-)-

There total 4 articles about 1-Piperidinecarboxylic acid, 3-methoxy-4-oxo-, ethyl ester, (-)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 83863-73-4,156970-95-5
(-)-ethyl 3,4,4-trimethoxy-1-piperidinecarboxylate

: 83863-72-3,156970-96-6
(-)-ethyl 3-methoxy-4-oxo-1-piperidine-carboxylate

Guidance literature:: With hydrogenchloride; methanol; In 1,4-dioxane; at 20 ℃; for 4h;

Reference yield:

: 29976-53-2
N-ethoxycarbonyl-4-piperidone

: 83863-72-3,156970-96-6
(-)-ethyl 3-methoxy-4-oxo-1-piperidine-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) H⁺ / 2.) heating

2: 1.) lead tetraacetate, BF₃*Et₂O, 2.) H₂SO₄ / 1.) room temperature, 2 h, 2.) H₂O, 1 h.

With lead(IV) acetate; sulfuric acid; boron trifluoride diethyl etherate; hydrogen cation;
DOI:10.1080/00397919808005072

Reference yield:

: 83898-43-5
ethyl 3-hydroxy-4,4-dimethoxy-1-piperidinecarboxylate

: 83863-72-3,156970-96-6
(-)-ethyl 3-methoxy-4-oxo-1-piperidine-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

1.2: 20 °C

2.1: sulfuric acid / water; tetrahydrofuran / 2 h / 60 °C

With sulfuric acid; sodium hydride; In tetrahydrofuran; water;
DOI:10.1021/jm500462x