tert-Butyl-[2-(3-methoxymethoxy-phenyl)-ethoxy]-dimethyl-silane

Base Information

• Chemical Name: tert-Butyl-[2-(3-methoxymethoxy-phenyl)-ethoxy]-dimethyl-silane
• CAS No.: 121442-60-2
• Molecular Formula: C₁₆H₂₈O₃Si
• Molecular Weight: 296.482
• Mol file: 121442-60-2.mol

Synonyms:tert-Butyl-[2-(3-methoxymethoxy-phenyl)-ethoxy]-dimethyl-silane

Chemical Property of tert-Butyl-[2-(3-methoxymethoxy-phenyl)-ethoxy]-dimethyl-silane

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of tert-Butyl-[2-(3-methoxymethoxy-phenyl)-ethoxy]-dimethyl-silane

There total 1 articles about tert-Butyl-[2-(3-methoxymethoxy-phenyl)-ethoxy]-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3-hydroxyphenyl)ethanol (13398-94-2) + chloromethyl methyl ether (107-30-2) + tert-butyldimethylsilyl chloride (18162-48-6) → tert-Butyl-[2-(3-methoxymethoxy-phenyl)-ethoxy]-dimethyl-silane (121442-60-2)

Guidance literature:

With 1H-imidazole; adogen 464; Yield given. Multistep reaction;

DOI:10.1021/ja00194a071

Reference yield: 91.0%

tert-Butyl-[2-(3-methoxymethoxy-phenyl)-ethoxy]-dimethyl-silane (121442-60-2) + Tert-butyl isocyanate (1609-86-5) → N-tert-Butyl-4-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-methoxymethoxy-benzamide (121442-61-3)

Guidance literature:

With sec.-butyllithium;

DOI:10.1021/ja00194a071

Reference yield:

tert-Butyl-[2-(3-methoxymethoxy-phenyl)-ethoxy]-dimethyl-silane (121442-60-2) → N-tert-Butyl-4-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-methoxymethoxy-6-(2-oxo-propyl)-benzamide (121442-62-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / s-BuLi

2: 1.) t-BuLi, 2.) n-BuLi

With n-butyllithium; tert.-butyl lithium; sec.-butyllithium;

DOI:10.1021/ja00194a071

upstream raw materials:

2-(3-hydroxyphenyl)ethanol

chloromethyl methyl ether

tert-butyldimethylsilyl chloride

Downstream raw materials:

N-tert-Butyl-4-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-methoxymethoxy-benzamide

N-tert-Butyl-4-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-methoxymethoxy-6-(2-oxo-propyl)-benzamide