5-chloroquinazoline-2,4-diol

Base Information

• Chemical Name: 5-chloroquinazoline-2,4-diol
• CAS No.: 78754-81-1
• Molecular Formula: C8H5 Cl N2 O2
• Molecular Weight: 196.5905
• Hs Code.: 2933990090
• Mol file: 78754-81-1.mol

Synonyms:5-Chloroquinazoline-2,4(1H,3H)-dione;FR 191863; NSC 338214

Chemical Property of 5-chloroquinazoline-2,4-diol

Chemical Property:

• Boiling Point: °Cat760mmHg
• PKA: 9.82±0.20(Predicted)
• Flash Point: °C
• PSA: 65.72000
• Density: 1.475g/cm³
• LogP: 0.86980
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

5-Chloroquinazoline-2,4(1H,3H)-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-chloroquinazoline-2,4-diol

There total 8 articles about 5-chloroquinazoline-2,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

2-amino-6-chlorobenzonitrile (6575-11-7) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-chloro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline (78754-81-1)

Guidance literature:

With carbon dioxide; In water; at 150 ℃; for 5h; under 37503.8 Torr;

DOI:10.1021/acs.oprd.6b00244

Reference yield: 79.0%

potassium cyanate (590-28-3) + 2-chloro-6-aminobenzoic acid (2148-56-3) → 5-chloro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline (78754-81-1)

Guidance literature:

With acetic acid; In water; at 80 - 90 ℃;

Reference yield: 78.0%

2-amino-6-chlorobenzamide (54166-95-9) + urea (57-13-6) → 5-chloro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline (78754-81-1)

Guidance literature:

fusion;

upstream raw materials:

2-amino-6-chlorobenzamide

urea

2-ureido-6-chlorobenzoic acid

2-chloro-6-aminobenzoic acid

Downstream raw materials:

1-(3,5-di-O-p-toluoyl-2-deoxy-α,β-D-erythro-pentofuranosyl)-5-chloro-quinazoline-2,4(3H)-dione

2,4,5-trichloroquinazoline

6,8-Diethyl-2-phenyl-1,6-dihydro-imidazo[4,5-f]quinazoline-7,9-dione

6,8-Dimethyl-2-phenyl-1,6-dihydro-imidazo[4,5-f]quinazoline-7,9-dione

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