(4R)-1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid 1-methylethyl ester

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Chemical Name:(4R)-1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid 1-methylethyl ester
CAS No.:128162-86-7
Molecular Formula:C₁₆H₁₉N₃O₅
Molecular Weight:333.344
Hs Code.:

Synonyms:(4R)-1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid 1-methylethyl ester

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Chemical Property of (4R)-1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid 1-methylethyl ester

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Technology Process of (4R)-1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid 1-methylethyl ester

There total 3 articles about (4R)-1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid 1-methylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 113094-77-2
<1(R)>-1,6-dihydro-2-methoxy-4-methyl-6(R)-(4-nitrophenyl)-1-<<(1-phenylethyl)amino>carbonyl>-5-pyrimidine carboxylic acid 1-methylethyl ester

: 128162-86-7
(4R)-1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid 1-methylethyl ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; for 4h; Heating;
DOI:10.1021/jm00171a044

Reference yield:

: 123486-12-4
2-methoxy-4-methyl-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid 5-(1-methylethyl) 1-(4-nitrophenyl) diester

: 128162-86-7
(4R)-1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid 1-methylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / ethyl acetate / 16 h / Ambient temperature

2: 81 percent / diazabicycloundecene / CH₂Cl₂ / 4 h / Heating

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; ethyl acetate;
DOI:10.1021/jm00171a044

Reference yield:

: 108931-52-8
1,4-Dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid,1-methylethyl ester

: 128162-86-7
(4R)-1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid 1-methylethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / NaHCO₃ / CH₂Cl₂; H₂O / 16 h / Ambient temperature

2: 54 percent / ethyl acetate / 16 h / Ambient temperature

3: 81 percent / diazabicycloundecene / CH₂Cl₂ / 4 h / Heating

With sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; water; ethyl acetate;
DOI:10.1021/jm00171a044