(2S,4R)-5-(4-bromophenyl)-2-hydroxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid

Base Information

Chemical Name:(2S,4R)-5-(4-bromophenyl)-2-hydroxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid
CAS No.:1562404-85-6
Molecular Formula:C₁₆H₁₉BrN₄O₄
Molecular Weight:411.255
Hs Code.:

Synonyms:(2S,4R)-5-(4-bromophenyl)-2-hydroxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid

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Chemical Property of (2S,4R)-5-(4-bromophenyl)-2-hydroxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid

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Technology Process of (2S,4R)-5-(4-bromophenyl)-2-hydroxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid

There total 6 articles about (2S,4R)-5-(4-bromophenyl)-2-hydroxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16681-70-2
1H-1,2,3-triazole-4-carboxylic acid

: 1562404-98-1
C₁₃H₁₈BrNO₃

: 1562404-85-6
(2S,4R)-5-(4-bromophenyl)-2-hydroxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid

Guidance literature:: 1H-1,2,3-triazole-4-carboxylic acid; With HATU; In N,N-dimethyl-formamide; for 0.166667h;

C₁₃H₁₈BrNO₃; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.5h;

Reference yield:

: 1383027-95-9
C₂₀H₂₄BrNO₇

: 1562404-85-6
(2S,4R)-5-(4-bromophenyl)-2-hydroxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / dichloromethane / 0.5 h / -5 °C / Inert atmosphere

1.2: 3.5 h / -5 - 23 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 23 °C

3.1: hydrogenchloride / 1,4-dioxane; acetonitrile / 0.5 h

4.1: HATU / N,N-dimethyl-formamide / 0.17 h

4.2: 0.5 h

With hydrogenchloride; potassium carbonate; acetic acid; HATU; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1394050-15-7
[(S)-1-(4-bromobenzyl)-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)ethyl]carbamic acid t-butyl ester

: 1562404-85-6
(2S,4R)-5-(4-bromophenyl)-2-hydroxymethyl-2-methyl-4-[(1H-[1,2,3]triazole-4-carbonyl)amino]pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 23 °C

2.1: hydrogenchloride / 1,4-dioxane; acetonitrile / 0.5 h

3.1: HATU / N,N-dimethyl-formamide / 0.17 h

3.2: 0.5 h

With hydrogenchloride; potassium carbonate; HATU; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;