1394050-15-7

Basic information

• Product Name: [(S)-1-(4-bromobenzyl)-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)ethyl]carbamic acid t-butyl ester
• Synonyms: [(S)-1-(4-bromobenzyl)-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)ethyl]carbamic acid t-butyl ester
• CAS NO: 1394050-15-7
• Molecular Weight: 456.334
• Mol File: 1394050-15-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: [(S)-1-(4-bromobenzyl)-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)ethyl]carbamic acid t-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(S)-1-(4-bromobenzyl)-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)ethyl]carbamic acid t-butyl ester(1394050-15-7)
• EPA Substance Registry System: [(S)-1-(4-bromobenzyl)-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-yl)ethyl]carbamic acid t-butyl ester(1394050-15-7)

Safety Data

• Hazardous Substances Data: 1394050-15-7(Hazardous Substances Data)

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 79561-82-3 (2R)-3-(4-bromophenyl)-2-[[(tert-butoxy)carbonyl]amino]propanoic acid 
• 62561-74-4 (2R)-2-amino-3-(4-bromophenyl)propanoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1383028-06-5 (S)-2-(4-bromobenzyl)-5-oxopyrrolidine-1-carboxylic acid tert-butyl ester 
• 1383028-37-2 (2R,4R)-4-amino-5-(4-bromophenyl)-2-hydroxypentanoic acid ethyl ester hydrochloride 
• 1383028-11-2 C₁₁H₁₂BrNO 
• 1383028-16-7 C₁₆H₂₀BrNO₂ 
• 1383028-21-4 C₁₆H₂₀BrNO₃ 
• 1383028-28-1 C₁₁H₁₄BrNO₃*ClH 
• 1394050-16-8 C₂₂H₂₄FNO₃ 
• 1394050-17-9 C₂₅H₂₉FN₂O₃ 
• 1394050-18-0 C₂₃H₂₄FNO₄ 
• 1394050-19-1 C₂₃H₂₆FNO₄ 
• 1432502-72-1 (2R,4R)-4-amino-5-(3'-chlorobiphenyl-4-yl)-2-hydroxypentanoic acid benzyl ester 
• 1432501-47-7 (2R,4R)-5-(3'-chlorobiphenyl-4-yl)-2-hydroxy-4-[(2-phenoxyethoxyoxalyl)amino]pentanoic acid 
• 1432502-19-6 (3R,5R)-5-(3'-chlorobiphenyl-4-ylmethyl)-1-(2,2-dimethylpropionyl)-3-hydroxypyrrolidin-2-one 
• 1432502-16-3 C₂₂H₂₄ClNO₃ 

Relevant articles and documents

(2S,4R)-5-(5'-CHLORO-2'-FLUOROBIPHENYL-4-YL)-4-(ETHOXYOXALYLAMINO)-2-HYDROXYMETHYL-2-METHYLPENTANOIC ACID

In one aspect, the invention relates to a compound of the structure: or a pharmaceutically acceptable salt thereof, and a crystalline form of this compound, having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical

NEPRILYSIN INHIBITORS

In one aspect, the invention relates to compounds having the formula I: where R1-R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.

NEPRILYSIN INHIBITORS

In one aspect, the invention relates to compounds having the formula: where R1-R5 and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.