(Z)-3-(4-bromophenyl)-5-benzylidene-2,5-dihydrofuran-2-one

Base Information

• Chemical Name: (Z)-3-(4-bromophenyl)-5-benzylidene-2,5-dihydrofuran-2-one
• CAS No.: 1222181-90-9
• Molecular Formula: C₁₇H₁₁BrO₂
• Molecular Weight: 327.177
• Mol file: 1222181-90-9.mol

Synonyms:(Z)-3-(4-bromophenyl)-5-benzylidene-2,5-dihydrofuran-2-one

Chemical Property of (Z)-3-(4-bromophenyl)-5-benzylidene-2,5-dihydrofuran-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-3-(4-bromophenyl)-5-benzylidene-2,5-dihydrofuran-2-one

There total 2 articles about (Z)-3-(4-bromophenyl)-5-benzylidene-2,5-dihydrofuran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

(4-bromophenyl)zinc iodide (148651-39-2) + (Z)-5-benzylidene-3-bromo-2,5-dihydrofuran-2-one (208194-66-5) → (Z)-3-(4-bromophenyl)-5-benzylidene-2,5-dihydrofuran-2-one (1222181-90-9)

Guidance literature:

With dichlorobis(tri(2-furyl)phosphine)palladium(II); In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.bmc.2010.01.030

Reference yield:

2-(4-Bromophenyl)-5-phenyl-3-hydroxypent-4-ynoic Acid → (Z)-3-(4-bromophenyl)-5-benzylidene-2,5-dihydrofuran-2-one (1222181-90-9)

Guidance literature:

With silver carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 60h; stereoselective reaction; Inert atmosphere;

DOI:10.1055/s-0036-1588338

Reference yield: 64.0%

2-hydroxy-3-butene (598-32-3) + (Z)-3-(4-bromophenyl)-5-benzylidene-2,5-dihydrofuran-2-one (1222181-90-9) → (Z)-5-benzylidene-3-[4-(3-oxobutyl)phenyl]furan-2(5H)-one

Guidance literature:

With tetrabutylammomium bromide; palladium diacetate; sodium hydrogencarbonate; tris-(o-tolyl)phosphine; In water; N,N-dimethyl-formamide; acetonitrile; at 75 ℃; for 2h; Inert atmosphere;

DOI:10.1055/s-0036-1588338

upstream raw materials:

(4-bromophenyl)zinc iodide

(Z)-5-benzylidene-3-bromo-2,5-dihydrofuran-2-one