2-methoxy-7-morpholin-4-yl-3-nitro-6-phenyl-[1,8]naphthyridine

Base Information

• Chemical Name: 2-methoxy-7-morpholin-4-yl-3-nitro-6-phenyl-[1,8]naphthyridine
• CAS No.: 326802-17-9
• Molecular Formula: C₁₉H₁₈N₄O₄
• Molecular Weight: 366.376
• Mol file: 326802-17-9.mol

Synonyms:2-methoxy-7-morpholin-4-yl-3-nitro-6-phenyl-[1,8]naphthyridine

Chemical Property of 2-methoxy-7-morpholin-4-yl-3-nitro-6-phenyl-[1,8]naphthyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methoxy-7-morpholin-4-yl-3-nitro-6-phenyl-[1,8]naphthyridine

There total 2 articles about 2-methoxy-7-morpholin-4-yl-3-nitro-6-phenyl-[1,8]naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

methanol (67-56-1) + 2-chloro-7-morpholin-4-yl-3-nitro-6-phenyl-[1,8]naphthyridine (326802-11-3) → 2-methoxy-7-morpholin-4-yl-3-nitro-6-phenyl-[1,8]naphthyridine (326802-17-9)

Guidance literature:

With sodium methylate; for 4h; Heating;

DOI:10.1016/S0014-827X(00)00085-9

Reference yield:

7-Morpholin-4-yl-3-nitro-6-phenyl-[1,8]naphthyridin-2-ol (199983-35-2) → 2-methoxy-7-morpholin-4-yl-3-nitro-6-phenyl-[1,8]naphthyridine (326802-17-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / POCl₃ / 0.75 h / 90 °C

2: 69 percent / MeONa / 4 h / Heating

With sodium methylate; trichlorophosphate;

DOI:10.1016/S0014-827X(00)00085-9

Reference yield: 85.0%

2-methoxy-7-morpholin-4-yl-3-nitro-6-phenyl-[1,8]naphthyridine (326802-17-9) → 2-methoxy-7-morpholin-4-yl-6-phenyl-[1,8]naphthyridin-3-ylamine

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; at 20 ℃; for 3h;

DOI:10.1016/S0014-827X(00)00085-9

upstream raw materials:

methanol

2-chloro-7-morpholin-4-yl-3-nitro-6-phenyl-[1,8]naphthyridine

7-Morpholin-4-yl-3-nitro-6-phenyl-[1,8]naphthyridin-2-ol