(3R,5R)-5-Biphenyl-4-ylmethyl-1-(2,2-dimethylpropionyl)-3-hydroxypyrrolidin-2-one

Base Information

Chemical Name:(3R,5R)-5-Biphenyl-4-ylmethyl-1-(2,2-dimethylpropionyl)-3-hydroxypyrrolidin-2-one
CAS No.:1383027-09-5
Molecular Formula:C₂₂H₂₅NO₃
Molecular Weight:351.445
Hs Code.:

Synonyms:(3R,5R)-5-Biphenyl-4-ylmethyl-1-(2,2-dimethylpropionyl)-3-hydroxypyrrolidin-2-one

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Chemical Property of (3R,5R)-5-Biphenyl-4-ylmethyl-1-(2,2-dimethylpropionyl)-3-hydroxypyrrolidin-2-one

Chemical Property:

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Technology Process of (3R,5R)-5-Biphenyl-4-ylmethyl-1-(2,2-dimethylpropionyl)-3-hydroxypyrrolidin-2-one

There total 6 articles about (3R,5R)-5-Biphenyl-4-ylmethyl-1-(2,2-dimethylpropionyl)-3-hydroxypyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1038924-65-0
(S)-5-biphenyl-4-ylmethyl-1-(2,2-dimethyl-propionyl)-pyrrolidin-2-one

: 1383027-09-5
(3R,5R)-5-Biphenyl-4-ylmethyl-1-(2,2-dimethylpropionyl)-3-hydroxypyrrolidin-2-one

Guidance literature:: (S)-5-biphenyl-4-ylmethyl-1-(2,2-dimethyl-propionyl)-pyrrolidin-2-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.333333h; Inert atmosphere;

With oxyaziridine; In tetrahydrofuran; for 0.5h;

Reference yield:

: 1038924-77-4
(S)-2-biphenyl-4-ylmethyl-5-oxopyrrolidine-1-carboxylic acid tert-butyl ester

: 1383027-09-5
(3R,5R)-5-Biphenyl-4-ylmethyl-1-(2,2-dimethylpropionyl)-3-hydroxypyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C

2.2: 1 h / -78 °C

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

3.2: 0.5 h

With hydrogenchloride; n-butyllithium; sodium hexamethyldisilazane; In tetrahydrofuran; hexanes; ethyl acetate;

Reference yield:

: 1383026-42-3
[(S)-2-biphenyl-4-yl-1-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-ylmethyl)ethyl]carbamic acid t-butyl ester

: 1383027-09-5
(3R,5R)-5-Biphenyl-4-ylmethyl-1-(2,2-dimethylpropionyl)-3-hydroxypyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 3 h / Inert atmosphere; Reflux

2.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C

3.2: 1 h / -78 °C

4.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

4.2: 0.5 h

With hydrogenchloride; n-butyllithium; sodium hexamethyldisilazane; In tetrahydrofuran; hexanes; ethyl acetate; toluene;