benzyl 5-<(E)-2-cyano-2-(methoxycarbonyl)ethenyl>-4-ethyl-3-methyl-2-pyrrolecarboxylate

Base Information

Chemical Name:benzyl 5-<(E)-2-cyano-2-(methoxycarbonyl)ethenyl>-4-ethyl-3-methyl-2-pyrrolecarboxylate
CAS No.:98619-41-1
Molecular Formula:C₂₀H₂₀N₂O₄
Molecular Weight:352.39
Hs Code.:

Synonyms:benzyl 5-<(E)-2-cyano-2-(methoxycarbonyl)ethenyl>-4-ethyl-3-methyl-2-pyrrolecarboxylate

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Chemical Property of benzyl 5-<(E)-2-cyano-2-(methoxycarbonyl)ethenyl>-4-ethyl-3-methyl-2-pyrrolecarboxylate

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Technology Process of benzyl 5-<(E)-2-cyano-2-(methoxycarbonyl)ethenyl>-4-ethyl-3-methyl-2-pyrrolecarboxylate

There total 3 articles about benzyl 5-<(E)-2-cyano-2-(methoxycarbonyl)ethenyl>-4-ethyl-3-methyl-2-pyrrolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 965-20-8
4-Ethyl-5-formyl-3-methyl-1H-pyrrol-2-carbonsaeure-benzylester

: 105-34-0
methyl 2-cyanoacetate

: 98619-41-1
benzyl 5-<(E)-2-cyano-2-(methoxycarbonyl)ethenyl>-4-ethyl-3-methyl-2-pyrrolecarboxylate

Guidance literature:: With triethylamine; In toluene; for 1h; Heating;

Reference yield:

: 1925-61-7
benzyl 4-ethyl-3,5-dimethylpyrrole-2-carboxylate

: 98619-41-1
benzyl 5-<(E)-2-cyano-2-(methoxycarbonyl)ethenyl>-4-ethyl-3-methyl-2-pyrrolecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: SO₂Cl₂ / CH₂Cl₂

2: H₂O / tetrahydrofuran / 0.17 h / Heating

3: Et₃N / toluene / 2 h

With sulfuryl dichloride; water; triethylamine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jo00247a024

Reference yield:

: 13219-63-1
5-dichloromethyl-4-ethyl-3-methyl-pyrrole-2-carboxylic acid benzyl ester

: 98619-41-1
benzyl 5-<(E)-2-cyano-2-(methoxycarbonyl)ethenyl>-4-ethyl-3-methyl-2-pyrrolecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: H₂O / tetrahydrofuran / 0.17 h / Heating

2: Et₃N / toluene / 2 h

With water; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1021/jo00247a024