3-N-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-6-(3-trifluoroacetamidophenyl)-(2H,3H)-N-methylpyrrolo[2,3-d]pyrimidine-2(7H)-one

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Chemical Name:3-N-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-6-(3-trifluoroacetamidophenyl)-(2H,3H)-N-methylpyrrolo[2,3-d]pyrimidine-2(7H)-one
CAS No.:1258747-53-3
Molecular Formula:C₄₁H₃₇F₃N₄O₇
Molecular Weight:754.763
Hs Code.:

Synonyms:3-N-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-6-(3-trifluoroacetamidophenyl)-(2H,3H)-N-methylpyrrolo[2,3-d]pyrimidine-2(7H)-one

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Chemical Property of 3-N-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-6-(3-trifluoroacetamidophenyl)-(2H,3H)-N-methylpyrrolo[2,3-d]pyrimidine-2(7H)-one

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Technology Process of 3-N-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-6-(3-trifluoroacetamidophenyl)-(2H,3H)-N-methylpyrrolo[2,3-d]pyrimidine-2(7H)-one

There total 5 articles about 3-N-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-6-(3-trifluoroacetamidophenyl)-(2H,3H)-N-methylpyrrolo[2,3-d]pyrimidine-2(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 383-63-1
ethyl trifluoroacetate,

: 1258747-51-1
3-N-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-6-(3-aminophenyl)-(2H,3H)-N-methylpyrrolo[2,3-d]pyrimidine-2(7H)-one

: 1258747-53-3
3-N-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-6-(3-trifluoroacetamidophenyl)-(2H,3H)-N-methylpyrrolo[2,3-d]pyrimidine-2(7H)-one

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 50 ℃; Inert atmosphere; Molecular sieve;
DOI:10.1039/c0ob00119h

Reference yield:

: 1258747-50-0
5-(3-aminophenyl)ethynyl-5'-O-(4,4'-dimethoxytrityl)-4N-methyl-2'-deoxycytidine

: 1258747-53-3
3-N-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-6-(3-trifluoroacetamidophenyl)-(2H,3H)-N-methylpyrrolo[2,3-d]pyrimidine-2(7H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 125 °C / Molecular sieve; Inert atmosphere; Darkness

2: dmap; triethylamine / dichloromethane / 0 - 50 °C / Inert atmosphere; Molecular sieve

With dmap; copper(l) iodide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c0ob00119h

Reference yield:

: 104375-88-4
2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-iodouridine

: 1258747-53-3
3-N-[2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-6-(3-trifluoroacetamidophenyl)-(2H,3H)-N-methylpyrrolo[2,3-d]pyrimidine-2(7H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / 0 - 20 °C / Inert atmosphere

2.1: 1-methyl-1H-imidazole; trichlorophosphate / pyridine / 1.17 h / 0 - 20 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: copper(l) iodide; triethylamine / N,N-dimethyl-formamide / Inert atmosphere; Darkness

3.2: 20 °C / Inert atmosphere; Darkness

4.1: copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 125 °C / Molecular sieve; Inert atmosphere; Darkness

5.1: dmap; triethylamine / dichloromethane / 0 - 50 °C / Inert atmosphere; Molecular sieve

With pyridine; 1-methyl-1H-imidazole; dmap; copper(l) iodide; triethylamine; trichlorophosphate; In pyridine; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c0ob00119h