2-(1-benzyl-2-oxopiperidine-3-yl)pyrrolidin-1-carboxylic acid methyl ester

Base Information

• Chemical Name: 2-(1-benzyl-2-oxopiperidine-3-yl)pyrrolidin-1-carboxylic acid methyl ester
• CAS No.: 812648-73-0
• Molecular Formula: C₁₈H₂₄N₂O₃
• Molecular Weight: 316.4
• Mol file: 812648-73-0.mol

Synonyms:2-(1-benzyl-2-oxopiperidine-3-yl)pyrrolidin-1-carboxylic acid methyl ester

Chemical Property of 2-(1-benzyl-2-oxopiperidine-3-yl)pyrrolidin-1-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(1-benzyl-2-oxopiperidine-3-yl)pyrrolidin-1-carboxylic acid methyl ester

There total 1 articles about 2-(1-benzyl-2-oxopiperidine-3-yl)pyrrolidin-1-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

{2-[(benzylamino)carbonyl]-5-hydroxy-1-(3-hydroxypropyl)pentyl}carbamic acid methyl ester → 2-(1-benzyl-2-oxopiperidine-3-yl)pyrrolidin-1-carboxylic acid methyl ester (812648-73-0)

Guidance literature:

{2-[(benzylamino)carbonyl]-5-hydroxy-1-(3-hydroxypropyl)pentyl}carbamic acid methyl ester; With triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran;

With sodium hydride; In tetrahydrofuran; for 7h; Heating;

DOI:10.1002/hlca.200490241

Reference yield:

2-(1-benzyl-2-oxopiperidine-3-yl)pyrrolidin-1-carboxylic acid methyl ester (812648-73-0) → nicotirine (487-19-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.24 g / LiAlH₄ / tetrahydrofuran / 12 h / Heating

2: 18 percent / Se / 30 h / 250 - 260 °C

With selenium; lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1002/hlca.200490241

Reference yield:

2-(1-benzyl-2-oxopiperidine-3-yl)pyrrolidin-1-carboxylic acid methyl ester (812648-73-0) → 1-benzyl-3-(1-methylpyrrolidin-2-yl)piperidine (812648-74-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 12h; Heating;

DOI:10.1002/hlca.200490241

Downstream raw materials:

1-benzyl-3-(1-methylpyrrolidin-2-yl)piperidine

3-(1-methylpyrrolidin-2-yl)piperidine

nicotirine