ethyl 6-(2,6-dichlorobenzyl)-4-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-2-methylnicotinate

Base Information

Chemical Name:ethyl 6-(2,6-dichlorobenzyl)-4-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-2-methylnicotinate
CAS No.:1391001-18-5
Molecular Formula:C₂₈H₃₂Cl₂N₄O₃
Molecular Weight:543.493
Hs Code.:

Synonyms:ethyl 6-(2,6-dichlorobenzyl)-4-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-2-methylnicotinate

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Chemical Property of ethyl 6-(2,6-dichlorobenzyl)-4-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-2-methylnicotinate

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Technology Process of ethyl 6-(2,6-dichlorobenzyl)-4-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-2-methylnicotinate

There total 7 articles about ethyl 6-(2,6-dichlorobenzyl)-4-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-2-methylnicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122833-04-9
2-methoxy-4-(4-methylpiperazin-1-yl)aniline

: 1391001-17-4
ethyl 6-(2,6-dichlorobenzyl)-4-chloro-2-methylpyridine-3-carboxylate

: 1391001-18-5
ethyl 6-(2,6-dichlorobenzyl)-4-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-2-methylnicotinate

Guidance literature:: toluene-4-sulfonic acid; In butan-1-ol; at 100 ℃; for 18h;

Reference yield:

: 1391001-14-1
ethyl 3-(1-(methoxycarbonyl)-3-(2,6-dichlorophenyl)propan-2-ylamino)but-2-enoate

: 1391001-18-5
ethyl 6-(2,6-dichlorobenzyl)-4-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-2-methylnicotinate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / tetrahydrofuran / 18 h / 20 °C

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / tetrahydrofuran / 18.08 h / 20 °C

3: trichlorophosphate / 2.5 h / 102 °C

4: toluene-4-sulfonic acid / butan-1-ol / 18 h / 100 °C

With potassium tert-butylate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; trichlorophosphate; toluene-4-sulfonic acid; In tetrahydrofuran; butan-1-ol;

Reference yield:

: 6575-24-2
2-(2,6-dichlorophenyl)acetic acid

: 1391001-18-5
ethyl 6-(2,6-dichlorobenzyl)-4-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-2-methylnicotinate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 20 °C

1.2: 18 h / 70 °C

2.1: magnesium sulfate; sodium cyanoborohydride; ammonium acetate / 18 h / 70 °C

3.1: magnesium sulfate; acetic acid / toluene / 3 h / 110 °C

4.1: potassium tert-butylate / tetrahydrofuran / 18 h / 20 °C

5.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / tetrahydrofuran / 18.08 h / 20 °C

6.1: trichlorophosphate / 2.5 h / 102 °C

7.1: toluene-4-sulfonic acid / butan-1-ol / 18 h / 100 °C

With potassium tert-butylate; ammonium acetate; sodium cyanoborohydride; magnesium sulfate; acetic acid; 1,1'-carbonyldiimidazole; 2,3-dicyano-5,6-dichloro-p-benzoquinone; trichlorophosphate; toluene-4-sulfonic acid; In tetrahydrofuran; toluene; butan-1-ol;