methyl (E)-3-{1-[(4-methylphenyl)sulfonyl]-2-(phenylmethylene)hydrazine}-2-propenoate

Base Information

• Chemical Name: methyl (E)-3-{1-[(4-methylphenyl)sulfonyl]-2-(phenylmethylene)hydrazine}-2-propenoate
• CAS No.: 1395103-03-3
• Molecular Formula: C₁₈H₁₈N₂O₄S
• Molecular Weight: 358.418
• Mol file: 1395103-03-3.mol

Synonyms:methyl (E)-3-{1-[(4-methylphenyl)sulfonyl]-2-(phenylmethylene)hydrazine}-2-propenoate

Chemical Property of methyl (E)-3-{1-[(4-methylphenyl)sulfonyl]-2-(phenylmethylene)hydrazine}-2-propenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (E)-3-{1-[(4-methylphenyl)sulfonyl]-2-(phenylmethylene)hydrazine}-2-propenoate

There total 2 articles about methyl (E)-3-{1-[(4-methylphenyl)sulfonyl]-2-(phenylmethylene)hydrazine}-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

propynoic acid methyl ester (922-67-8) + sodium (E)-2-benzylidene-1-tosylhydrazin-1-ide → methyl (E)-3-{1-[(4-methylphenyl)sulfonyl]-2-(phenylmethylene)hydrazine}-2-propenoate (1395103-03-3) + methyl (Z)-3-(2-((E)-benzylidene)-1-tosylhydrazinyl)acrylate

Guidance literature:

In acetonitrile; at 90 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2020.112699

Reference yield:

benzaldehyde (100-52-7) + toluene-4-sulfonic acid hydrazide (1576-35-8) → methyl (E)-3-{1-[(4-methylphenyl)sulfonyl]-2-(phenylmethylene)hydrazine}-2-propenoate (1395103-03-3) + methyl (Z)-3-(2-((E)-benzylidene)-1-tosylhydrazinyl)acrylate

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetonitrile / 6 h / 90 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: acetonitrile / 90 °C / Inert atmosphere

In acetonitrile; 2.1: |Michael Addition;

DOI:10.1016/j.ejmech.2020.112699

upstream raw materials:

benzaldehyde

toluene-4-sulfonic acid hydrazide

propynoic acid methyl ester