2-(2-(2-(5-methyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)acetamide

Base Information

Chemical Name:2-(2-(2-(5-methyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)acetamide
CAS No.:1566584-15-3
Molecular Formula:C₂₃H₂₉N₇O
Molecular Weight:419.53
Hs Code.:

Synonyms:2-(2-(2-(5-methyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)acetamide

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Chemical Property of 2-(2-(2-(5-methyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)acetamide

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Technology Process of 2-(2-(2-(5-methyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)acetamide

There total 12 articles about 2-(2-(2-(5-methyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1566585-36-1
tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-methylpyrimidin-2-yl)amino)-1H-pyrazol-1-yl)piperidine-1-carboxylate

: 1566584-15-3
2-(2-(2-(5-methyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)acetamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1566584-15-3
2-(2-(2-(5-methyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 144 h / 0 - 20 °C

1.2: 18 h / 20 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 0.58 h / 120 °C / Inert atmosphere; Microwave irradiation

3.1: triethylamine; palladium 10% on activated carbon; hydrogen / water; N,N-dimethyl-formamide / 18 h / 20 °C

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 18 h / 40 °C

5.1: N-ethyl-N,N-diisopropylamine; ammonium carbonate; benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With ammonium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; palladium 10% on activated carbon; water; hydrogen; benzotriazol-1-ol; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1566584-15-3
2-(2-(2-(5-methyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate / methanol / 4 h / 0 - 20 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 144 h / 0 - 20 °C

2.2: 18 h / 20 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 0.58 h / 120 °C / Inert atmosphere; Microwave irradiation

4.1: triethylamine; palladium 10% on activated carbon; hydrogen / water; N,N-dimethyl-formamide / 18 h / 20 °C

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 18 h / 40 °C

6.1: N-ethyl-N,N-diisopropylamine; ammonium carbonate; benzotriazol-1-ol; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With ammonium carbonate; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; N¹-((ethylimino)methylene)-N³,N³-dimethylpropane-1,3-diamine hydrochloride; palladium 10% on activated carbon; water; hydrogen; benzotriazol-1-ol; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;