(R)-2-(1-amino-4-methyl-1-oxopentan-2-ylamino)-6-oxo-4-(4-(pyridin-3-yl)phenylamino)-1,6-dihydropyrimidine-5-carboxamide

Base Information

Chemical Name:(R)-2-(1-amino-4-methyl-1-oxopentan-2-ylamino)-6-oxo-4-(4-(pyridin-3-yl)phenylamino)-1,6-dihydropyrimidine-5-carboxamide
CAS No.:1374159-80-4
Molecular Formula:C₂₂H₂₅N₇O₃
Molecular Weight:435.486
Hs Code.:

Synonyms:(R)-2-(1-amino-4-methyl-1-oxopentan-2-ylamino)-6-oxo-4-(4-(pyridin-3-yl)phenylamino)-1,6-dihydropyrimidine-5-carboxamide

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Chemical Property of (R)-2-(1-amino-4-methyl-1-oxopentan-2-ylamino)-6-oxo-4-(4-(pyridin-3-yl)phenylamino)-1,6-dihydropyrimidine-5-carboxamide

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Technology Process of (R)-2-(1-amino-4-methyl-1-oxopentan-2-ylamino)-6-oxo-4-(4-(pyridin-3-yl)phenylamino)-1,6-dihydropyrimidine-5-carboxamide

There total 8 articles about (R)-2-(1-amino-4-methyl-1-oxopentan-2-ylamino)-6-oxo-4-(4-(pyridin-3-yl)phenylamino)-1,6-dihydropyrimidine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-2-(1-amino-4-methyl-1-oxopentan-2-ylamino)-4-(benzyloxy)-6-(4-(pyridine-3-yl)phenylamino)-pyrimidine-5-carboxamide.

: 1374159-80-4
(R)-2-(1-amino-4-methyl-1-oxopentan-2-ylamino)-6-oxo-4-(4-(pyridin-3-yl)phenylamino)-1,6-dihydropyrimidine-5-carboxamide

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 20 ℃; for 2h;

Reference yield:

: 540-37-4
p-aminoiodobenzene

: 1374159-80-4
(R)-2-(1-amino-4-methyl-1-oxopentan-2-ylamino)-6-oxo-4-(4-(pyridin-3-yl)phenylamino)-1,6-dihydropyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N,N-dimethyl-formamide / 3 h / 20 °C

2.1: sodium hydride / 1-Methylpyrrolidine / 0.5 h / 20 °C

2.2: 1 h / 75 °C

2.3: 0.5 h / 75 °C

3.1: peracetic acid / acetic acid / 1-Methylpyrrolidine / 15 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / 1-Methylpyrrolidine / 1 h / 60 °C

5.1: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide / 1 h / 70 °C

6.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; ethanol; water / 1 h / 90 °C

7.1: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 2 h / 20 °C

With hydrogenchloride; peracetic acid; dihydrogen peroxide; sodium hydride; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; acetic acid; In tetrahydrofuran; 1-Methylpyrrolidine; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 33097-13-1
4,6-dichloro-2-(methylthio)-5-pyrimidinecarbonitrile

: 1374159-80-4
(R)-2-(1-amino-4-methyl-1-oxopentan-2-ylamino)-6-oxo-4-(4-(pyridin-3-yl)phenylamino)-1,6-dihydropyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N,N-dimethyl-formamide / 3 h / 20 °C

2.1: sodium hydride / 1-Methylpyrrolidine / 0.5 h / 20 °C

2.2: 1 h / 75 °C

2.3: 0.5 h / 75 °C

3.1: peracetic acid / acetic acid / 1-Methylpyrrolidine / 15 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / 1-Methylpyrrolidine / 1 h / 60 °C

5.1: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide / 1 h / 70 °C

6.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; ethanol; water / 1 h / 90 °C

7.1: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 2 h / 20 °C

With hydrogenchloride; peracetic acid; dihydrogen peroxide; sodium hydride; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; acetic acid; In tetrahydrofuran; 1-Methylpyrrolidine; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;