7-[(4R)-1-{[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-4-fluoro-L-prolyl]-4,7-diazaspiro[2.5]octane

Base Information

Chemical Name:7-[(4R)-1-{[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-4-fluoro-L-prolyl]-4,7-diazaspiro[2.5]octane
CAS No.:1235575-91-3
Molecular Formula:C₃₂H₃₄Cl₂F₂N₆O₂S
Molecular Weight:675.63
Hs Code.:

7-[(4R)-1-{[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-4-fluoro-L-prolyl]-4,7-diazaspiro[2.5]octane

Synonyms:7-[(4R)-1-{[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-4-fluoro-L-prolyl]-4,7-diazaspiro[2.5]octane

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Chemical Property of 7-[(4R)-1-{[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-4-fluoro-L-prolyl]-4,7-diazaspiro[2.5]octane

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Technology Process of 7-[(4R)-1-{[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-4-fluoro-L-prolyl]-4,7-diazaspiro[2.5]octane

There total 23 articles about 7-[(4R)-1-{[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-4-fluoro-L-prolyl]-4,7-diazaspiro[2.5]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1235576-26-7
7-[(4R)-1-{[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-4-fluoro-L-prolyl]-4-(trifluoroacetyl)-4,7-diazaspiro[2.5]octane

: 1235575-91-3
7-[(4R)-1-{[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-4-fluoro-L-prolyl]-4,7-diazaspiro[2.5]octane

Guidance literature:: With water; potassium carbonate; In methanol; at 40 ℃; for 2h;

Reference yield:

: 1222106-43-5
7-benzyl-4,7-diazaspiro[2.5]octane-5,8-dione

: 1235575-91-3
7-[(4R)-1-{[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-4-fluoro-L-prolyl]-4,7-diazaspiro[2.5]octane

Guidance literature:: Multi-step reaction with 7 steps

1.1: borane-THF / tetrahydrofuran / 19 h / Reflux

2.1: triethylamine / dichloromethane / 1 h / Cooling with ice

3.1: hydrogenchloride; water; hydrogen / 5%-palladium/activated carbon / ethanol / 15 h

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.25 h / 20 °C

4.2: 16 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

6.1: thionyl chloride / N,N-dimethyl-formamide / 1,2-dichloro-ethane / 1 h / 70 °C

6.2: 20 h / 20 °C / Cooling with ice

7.1: water; potassium carbonate / methanol / 2 h / 40 °C

With hydrogenchloride; thionyl chloride; borane-THF; water; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; 5%-palladium/activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 84677-06-5
(benzyloxycarbonylamino)cyclopropanecarboxylic acid

: 1235575-91-3
7-[(4R)-1-{[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-4-fluoro-L-prolyl]-4,7-diazaspiro[2.5]octane

Guidance literature:: Multi-step reaction with 9 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C / Cooling with ice

2.1: hydrogen / 5%-palladium/activated carbon / ethanol / 2 h

3.1: borane-THF / tetrahydrofuran / 19 h / Reflux

4.1: triethylamine / dichloromethane / 1 h / Cooling with ice

5.1: hydrogenchloride; water; hydrogen / 5%-palladium/activated carbon / ethanol / 15 h

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.25 h / 20 °C

6.2: 16 h / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

8.1: thionyl chloride / N,N-dimethyl-formamide / 1,2-dichloro-ethane / 1 h / 70 °C

8.2: 20 h / 20 °C / Cooling with ice

9.1: water; potassium carbonate / methanol / 2 h / 40 °C

With hydrogenchloride; thionyl chloride; borane-THF; water; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; 5%-palladium/activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;