1222106-43-5

Basic information

• Product Name: 7-benzyl-4,7-diazaspiro[2.5]octane-5,8-dione
• Synonyms: 7-benzyl-4,7-diazaspiro[2.5]octane-5,8-dione
• CAS NO: 1222106-43-5
• Molecular Weight: 230.266
• Mol File: 1222106-43-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 7-benzyl-4,7-diazaspiro[2.5]octane-5,8-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 7-benzyl-4,7-diazaspiro[2.5]octane-5,8-dione(1222106-43-5)
• EPA Substance Registry System: 7-benzyl-4,7-diazaspiro[2.5]octane-5,8-dione(1222106-43-5)

Safety Data

• Hazardous Substances Data: 1222106-43-5(Hazardous Substances Data)

Usage

General Description

7-benzyl-4,7-diazaspiro[2.5]octane-5,8-dione is a chemical compound that belongs to the spiroketals class of organic compounds. It is a cyclic diester and contains a diazaspiro ring with a benzyl substituent. 7-benzyl-4,7-diazaspiro[2.5]octane-5,8-dione has potential pharmacological properties and may be used in the development of new drugs. It has been studied for its neuroprotective effects and potential as an anti-inflammatory agent. The unique structure and properties of 7-benzyl-4,7-diazaspiro[2.5]octane-5,8-dione make it an interesting target for further research and development in the field of medicinal chemistry.

Upstream product

• 100-46-9 benzylamine 
• 108994-30-5 N-benzyl-glycyl chloride ; hydrochloride 
• 17136-36-6 N-benzylglycine 
• 84677-06-5 (benzyloxycarbonylamino)cyclopropanecarboxylic acid 
• 6436-90-4 ethyl 2-(benzylamino)acetate 

Downstream Products

• 1222106-45-7 7-benzyl-4,7-diazaspiro[2.5]octane 
• 1222106-47-9 7-Benzyl-4-(trifluoroacetyl)-4,7-diazaspiro[2.5]octane 
• 1235576-26-7 7-[(4R)-1-{[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-4-fluoro-L-prolyl]-4-(trifluoroacetyl)-4,7-diazaspiro[2.5]octane 
• 1235575-91-3 7-[(4R)-1-{[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-4-fluoro-L-prolyl]-4,7-diazaspiro[2.5]octane 
• 1235576-07-4 7-[(4R)-1-{[(5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-4-fluoro-L-prolyl]-4-methyl-4,7-diazaspiro[2.5]octane 
• 99214-52-5 4,7-diazaspiro[2.5]octane 
• 2173992-48-6 tert-butyl 4,7-diazaspiro[2.5]octane-4-carboxylate oxalate 

Relevant articles and documents

Preparation method of 4,7-diazaspiro[2.5]octane derivative

The invention provides a preparation method of 4,7-diazaspiro[2.5]octane derivative. The 4,7-diazaspiro[2.5]octane derivative is prepared by taking 1-aminocyclopropane carboxylate as a starting material. The preparation method has the advantages of simple operation steps, stable process conditions, high controllability, high product yield (the four-step reaction yield of compounds shown as formulas II to I can be up to 70 percent), environmental friendliness and the like, and is suitable for large-scale production.

Sulfamide derivative and application thereof

The invention relates to a sulfamide derivative and a pharmaceutical composition comprising the compound as well as use of the sulfamide derivative and the pharmaceutical composition as a preparation drug, in particular, use of a drug for preparing a BCL-2 family protein antagonist and use of the drug for treating cancers.

MORPHOLINOPURINE DERIVATIVES

There is provided a novel compound that inhibits phosphatidylinositol 3-kinase (PI3K) and/or the mammalian target of rapamycin (mTOR) and exhibits anti-tumor activity. The present invention provides a compound represented by the following formula (1) having various substituents that inhibits PI3K and/or mTOR and exhibits anti-tumor activity: wherein R1, R2, R3, R4, Ra, Rb, Rc, and X each have the same meaning as defined in the specification.