Telmisartan Hydrochloride

Base Information

• Chemical Name: Telmisartan Hydrochloride
• CAS No.: 515815-48-2
• Molecular Formula: C₃₃H₃₀N₄O₂*ClH
• Molecular Weight: 551.088
• European Community (EC) Number: 610-701-9
• DSSTox Substance ID: DTXSID601019989

Synonyms:Telmisartan Hydrochloride;SCHEMBL1203935;TTWVBVXEOQKSLK-UHFFFAOYSA-N;DTXSID601019989;4'-[[4-Methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl]methyl]-2-biphenylcarboxylic acid hydrochloride;515815-48-2

Chemical Property of Telmisartan Hydrochloride

Chemical Property:

• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 550.2135539
• Heavy Atom Count: 40
• Complexity: 831

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC1=NC2=C(N1CC3=CC=C(C=C3)C4=CC=CC=C4C(=O)O)C=C(C=C2C)C5=NC6=CC=CC=C6N5C.Cl

Technology Process of Telmisartan Hydrochloride

There total 2 articles about Telmisartan Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.5%

4'-[[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl (144702-27-2) → tert-butyl-4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate hydrochloride (515815-48-2)

Guidance literature:

4'-[[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl; With potassium hydroxide; water; In ethylene glycol; at 150 - 160 ℃; for 13.5 - 15h;

With hydrogenchloride; In water; at 20 - 100 ℃; for 1h;

Reference yield:

telmisatran (144701-48-4) → tert-butyl-4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate hydrochloride (515815-48-2)

Guidance literature:

With hydrogenchloride; In methanol; water; Heating / reflux;

Reference yield: 99.0%

tert-butyl-4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate hydrochloride (515815-48-2) → telmisartan sodium (515815-47-1)

Guidance literature:

With sodium methylate; In methanol; water; isopropyl alcohol; toluene; at 75 ℃;

upstream raw materials:

4'-[[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl

telmisatran

Downstream raw materials:

telmisatran

telmisartan sodium

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